Preeclampsia: an endothelial cell disorder.

Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants.

Preeclampsia: an excessive maternal inflammatory response to pregnancy.

Endometriosis

Preterm birth is associated with 5 to 18% of pregnancies and is a leading cause of infant morbidity and mortality. Spontaneous preterm labor, a syndrome caused by multiple pathologic processes, leads to 70% of preterm births. The prevention and the treatment of preterm labor have been long-standing challenges. We summarize the current understanding of the mechanisms of disease implicated in this condition and review advances relevant to intra-amniotic infection, decidual senescence, and breakdown of maternal-fetal tolerance. The success of progestogen treatment to prevent preterm birth in a subset of patients at risk is a cause for optimism. Solving the mystery of preterm labor, which compromises the health of future generations, is a formidable scientific challenge worthy of investment.

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Ivo Brosens

Papers

Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants.

The "Great Obstetrical Syndromes" are associated with disorders of deep placentation.

The role of the spiral arteries in the pathogenesis of preeclampsia.

Trophoblastic invasion of human decidua from 8 to 18 weeks of pregnancy.

The physiological response of the vessels of the placental bed to normal pregnancy