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Iwao Yamada
Researcher at Brigham and Women's Hospital
Publications - 23
Citations - 714
Iwao Yamada is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Pitavastatin & HMG-CoA reductase. The author has an hindex of 14, co-authored 23 publications receiving 608 citations. Previous affiliations of Iwao Yamada include Keio University & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation
Hiroshi Iwata,Claudia Goettsch,Amitabh Sharma,Piero Ricchiuto,Wilson Wen Bin Goh,Arda Halu,Iwao Yamada,Hideo Yoshida,Takuya Hara,Mei Wei,Noriyuki Inoue,Daiju Fukuda,Alexander Mojcher,Peter C. Mattson,Albert-László Barabási,Albert-László Barabási,Mark Boothby,Elena Aikawa,Sasha A Singh,Masanori Aikawa +19 more
TL;DR: Global proteomic analysis of macrophage cell lines treated with either IFNγ or IL-4 suggests that PARP9 and PARP14 cross-regulate macrophages activation, and links PARP 9–PARP14 with human coronary artery disease.
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Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: human UDP-glucuronosyltransferase enzymes involved in lactonization.
TL;DR: The mechanism of pitavastatin lactone formation has been clarified, in that glucuronidation by UGT occurs first followed by lactonization via an elimination reaction, and it was found that pitavastsatin lact one demonstrates no drug-drug interactions.
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Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress.
Maximillian A. Rogers,Natalia Maldonado,Joshua D. Hutcheson,Claudia Goettsch,Shinji Goto,Iwao Yamada,Tyler Faits,Hiromi Sesaki,Masanori Aikawa,Elena Aikawa +9 more
TL;DR: A new function of DRP1 is demonstrated in regulating collagen secretion and cardiovascular calcification, a novel area of exploration for the potential development of new therapies to modify cellular fibrocalcific response in cardiovascular diseases.
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Total Synthesis of Spicamycin
TL;DR: The proposed unique structure of a novel nucleoside antibiotic is confirmed, and the first total synthesis of one of the spicamycin congeners, SPM VIII, is described.
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Studies on the Metabolic Fate of NK-104, a New Inhibitor of HMG-CoA Reductase (5) : In Vitro Metabolism and Plasma Protein Binding in Animals and Human
TL;DR: CYP2C9 and CYP2C8 are the enzymes responsible for the metabolism of NK-104, and no inhibitory effect on CYP mediated 4-hydroxylation of tolbutamide in the presence ofNK-104 was detected.