I
Izumu Saito
Researcher at University of Tokyo
Publications - 197
Citations - 13615
Izumu Saito is an academic researcher from University of Tokyo. The author has contributed to research in topics: Gene & Hepatitis C virus. The author has an hindex of 56, co-authored 197 publications receiving 13288 citations. Previous affiliations of Izumu Saito include National Institutes of Health & Lincoln's Inn.
Papers
More filters
Journal ArticleDOI
Hepatitis C virus infection is associated with the development of hepatocellular carcinoma
Izumu Saito,Tatsuo Miyamura,Akira Ohbayashi,H Harada,Tohru Katayama,Shu Kikuchi,Yushiro Watanabe,S Koi,Morikazu Onji,Yasuyuki Ohta +9 more
TL;DR: There appears to be a strong association between HCV infection and the development of HCC, particularly in patients for which HBV infection cannot be implicated as a causative factor.
Journal ArticleDOI
HBx gene of hepatitis B virus induces liver cancer in transgenic mice
TL;DR: This transgenic animal model appears ideal for defining the molecular events that follow the expression of the viral HBx gene and are responsible for the development of liver cancer.
Journal ArticleDOI
Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome.
Sanae Miyake,M. Makimura,Yumi Kanegae,Shizuko Harada,Yumi Sato,Koichi Takamori,Chikashi Tokuda,Izumu Saito +7 more
TL;DR: An efficient method of constructing recombinant adenoviruses (Ads) by establishing construction systems for two types of Ad vectors, the E1-substitution type and the E4-insertion type, which may greatly facilitate the application of recombinant Ads and should be useful for further improvement ofAd vectors.
Journal ArticleDOI
Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase.
Yumi Kanegae,Gwang Lee,Yumi Sato,Miyoko Tanaka,Michio Nakai,T Sakaki,Sumio Sugano,Izumu Saito +7 more
TL;DR: Results suggest that the recombinant Ad efficiently expressed functional Cre and offers a basis for establishing a powerful on/off switching strategy of gene expression in cultured mammalian cells and presumably in transgenic animals.
Journal ArticleDOI
Rapid Colorectal Adenoma Formation Initiated by Conditional Targeting of the Apc Gene
Hiroyuki Shibata,Kaoru Toyama,Hisashi Shioya,Masaki Ito,Morihisa Hirota,Sumitaka Hasegawa,Hiroshi Matsumoto,Hiroshi Takano,Tetsu Akiyama,Kumao Toyoshima,Ryunosuke Kanamaru,Yumi Kanegae,Izumu Saito,Yusuke Nakamura,Kiyotaka Shiba,Tetsuo Noda +15 more
TL;DR: A mouse model of FAP was created that circumvents the embryonic lethality of Apc deficiency and directs Apc inactivation specifically to the colorectal epithelium.