K
Kazuhiko Koike
Researcher at University of Tokyo
Publications - 1203
Citations - 42534
Kazuhiko Koike is an academic researcher from University of Tokyo. The author has contributed to research in topics: Hepatocellular carcinoma & Stent. The author has an hindex of 79, co-authored 1157 publications receiving 36326 citations. Previous affiliations of Kazuhiko Koike include Jikei University School of Medicine & Japanese Foundation for Cancer Research.
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Hepatocellular carcinoma.
Josep M. Llovet,Robin Kate Kelley,Augusto Villanueva,Amit G. Singal,Eli Pikarsky,Sasan Roayaie,Riccardo Lencioni,Kazuhiko Koike,Jessica Zucman-Rossi,Richard S. Finn +9 more
TL;DR: In this paper, the authors used non-invasive criteria to diagnose hepatocellular carcinoma (HCC) and showed that 25% of all HCCs present potentially actionable mutations, which are yet to translate into clinical practice.
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Correction: Corrigendum: MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma
Kentaro Kojima,Akemi Takata,Charles Vadnais,Motoyuki Otsuka,Takeshi Yoshikawa,Masao Akanuma,Yuji Kondo,Young Jun Kang,Takahiro Kishikawa,Naoya Kato,Zhifang Xie,Weiping J. Zhang,Haruhiko Yoshida,Masao Omata,Alain Nepveu,Kazuhiko Koike +15 more
TL;DR: This Article contains errors in the numbering of several papers in the reference list; reference 34 is incorrectly listed as reference 44 and references 35 to 44 are incorrectly list as 34 to 43.
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The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice.
Kyoji Moriya,Hajime Fujie,Yoshizumi Shintani,Hiroshi Yotsuyanagi,Takeya Tsutsumi,Kotaro Ishibashi,Yoshiharu Matsuura,Satoshi Kimura,Tatsuo Miyamura,Kazuhiko Koike +9 more
TL;DR: It is indicated that the HCV core protein has a chief role in the development of HCC, and that these transgenic mice provide good animal models for determining the molecular events in hepatocarcinogenesis with HCV infection.
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HBx gene of hepatitis B virus induces liver cancer in transgenic mice
TL;DR: This transgenic animal model appears ideal for defining the molecular events that follow the expression of the viral HBx gene and are responsible for the development of liver cancer.
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Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance
Yoshizumi Shintani,Hajime Fujie,Hideyuki Miyoshi,Takeya Tsutsumi,Kazuhisa Tsukamoto,Satoshi Kimura,Kyoji Moriya,Kazuhiko Koike +7 more
TL;DR: The ability of insulin to lower the plasma glucose level in the HCV transgenic mice was impaired, as observed in chronic hepatitis C patients, providing a direct experimental evidence for the contribution of HCV in the development of insulin resistance in human HCV infection, which finally leads to theDevelopment of type 2 diabetes.