J
J. A. Fernández
Researcher at University of Castilla–La Mancha
Publications - 44
Citations - 1891
J. A. Fernández is an academic researcher from University of Castilla–La Mancha. The author has contributed to research in topics: Crocus sativus & Crocus. The author has an hindex of 21, co-authored 44 publications receiving 1683 citations.
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Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro
TL;DR: Considering its water-solubility and high inhibitory growth effect, crocin is the more promising saffron compound to be assayed as a cancer therapeutic agent.
Biology, biotechnology and biomedicine of saffron
TL;DR: Some of the latest advances carried out on the biology, biotechnology and biomedicine of this ancient crop, saffron, are reviewed.
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Effects of Long-Term Treatment of Colon Adenocarcinoma With Crocin, a Carotenoid From Saffron (Crocus sativus L.): An Experimental Study in the Rat
Dolores C. García-Olmo,Hans H. Riese,Julio Escribano,Jesús Ontañón,J. A. Fernández,M Atiénzar,Damián García-Olmo +6 more
TL;DR: Long-term treatment with crocin enhances survival selectively in female rats with colon cancer without major toxic effects, and might be related to its strong cytotoxic effect on cultured tumor cells.
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Implications of Carotenoid Biosynthetic Genes in Apocarotenoid Formation during the Stigma Development of Crocus sativus and Its Closer Relatives
TL;DR: In this paper, the authors investigated the accumulation and the molecular mechanisms that regulate the synthesis of these apocarotenoids during stigma development in C. sativus and found that only the relative levels of zeaxanthin in the stigma of each cultivar were correlated with the level of CsBCH transcripts.
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Comparison of three different PCR methods for detection of Brucella spp. in human blood samples
TL;DR: In this article, the authors compared three different PCR methods for the detection of Brucella spp. and found that although the sensitivity of the primers F4/R2 is affected by human DNA, they are still the most sensitive and they could provide a useful tool for the diagnosis of human brucellosis.