J
J. Alastair Gracie
Researcher at University of Glasgow
Publications - 26
Citations - 3148
J. Alastair Gracie is an academic researcher from University of Glasgow. The author has contributed to research in topics: Cytokine & Proinflammatory cytokine. The author has an hindex of 20, co-authored 26 publications receiving 3019 citations. Previous affiliations of J. Alastair Gracie include Life Sciences Institute & Glasgow Royal Infirmary.
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Journal ArticleDOI
The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release
Darren L. Asquith,L. Ballantine,Jagtar Singh Nijjar,Manhal Khuder Makdasy,Sabina Patel,Pamela B Wright,James H. Reilly,Shauna C Kerr,Mariola Kurowska-Stolarska,J. Alastair Gracie,Iain B. McInnes +10 more
TL;DR: The LXR pathway is the most upregulated pathway in RA synovial macrophages and activation of LXRs by ligands present within SF augments TLR-driven cytokine and chemokine secretion.
Journal ArticleDOI
Interleukin-18: a novel cytokine in inflammatory rheumatic disease.
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The Anti-inflammatory Potential of the Filarial Nematode Secreted Product, ES-62
TL;DR: In this article, a major filarial nematode secreted glycoprotein, ES-62, was found to possess broad immunomodulatory activities that are in general, anti-inflammatory.
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Targeting cytokines beyond tumor necrosis factor-alpha and interleukin-1 in rheumatoid arthritis.
TL;DR: Recent data that support the notion that some or all of these moieties offer therapeutic potential in rheumatoid arthritis synovitis are reviewed, and the possibility that some may be useful in partial responders to tumor necrosis factor blocking agents or in synergy with the latter is discussed.
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Phosphodiesterase 4 (PDE4) regulation of proinflammatory cytokine and chemokine release from rheumatoid synovial membrane
Anne Crilly,SE Robertson,James H. Reilly,J. Alastair Gracie,Wen-Qi Lai,Bernard P. Leung,Bernard P. Leung,Paul F Life,Iain B. McInnes +8 more
TL;DR: Direct evidence of PDE4-dependent pathways in human RA synovial inflammatory cytokine and chemokine release is provided and may provide a novel approach in treating chronic autoimmune conditions such as RA.