J D Capra

TL;DR: It is found that the somatic mutation machinery is activated only after B cells reach the germinal center and become centroblasts (Bm3), and the analysis of Ig variable region transcripts from the different subpopulations confirms that the pathway of B cell differentiation from virgin B cell throughout the gerMinal center up to the memory compartment can be traced with phenotypic markers.

TL;DR: It is concluded that the presence of the HLA Class II antigen DQw1.2 is strongly protective against the development of IDDM, and that complete HLA-DQ typing is necessary for accurate assessment of susceptibility to IDDM.

TL;DR: Initial chemical characterization of the monocyte antigen recognized by two of these antibodies is presented, and it is suggested that this molecule is a single polypeptide chain with an apparent molecular weight of 200,000.

TL;DR: Although the VH4-21 gene segment is essential for cold agglutinin activity, the other genetic elements that contribute to the V region of the antibody molecules can be extremely diverse and the structural information provided in this report sharply restricts the requirement for encoding pathogenic cold agglusiveness activity to one of the components of the H chain V region.

TL;DR: The nucleotide sequence of 30 distinct human VH gene segments from the VHIV, VHV and VHVI gene families are reported to provide evidence that at least some human Vh gene segments are remarkably stable.