V
Virginia Pascual
Researcher at Cornell University
Publications - 209
Citations - 30534
Virginia Pascual is an academic researcher from Cornell University. The author has contributed to research in topics: Immune system & Lupus erythematosus. The author has an hindex of 76, co-authored 197 publications receiving 26649 citations. Previous affiliations of Virginia Pascual include Baylor University & Texas Scottish Rite Hospital for Children.
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Journal ArticleDOI
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
Lynda Bennett,A. Karolina Palucka,Edsel Arce,Edsel Arce,Victoria Cantrell,Victoria Cantrell,Josef Borvak,Jacques Banchereau,Virginia Pascual,Virginia Pascual +9 more
TL;DR: Microarray analysis of blood cells reveals that immature granulocytes may be involved in SLE pathogenesis, and the IFN signature confirms the central role of this cytokine in Sle, using oligonucleotide microarrays.
Journal ArticleDOI
An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
Matthew Berry,Christine M. Graham,Finlay W. McNab,Zhaohui Xu,Susannah Bloch,Tolu Oni,Tolu Oni,Katalin A. Wilkinson,Katalin A. Wilkinson,Romain Banchereau,Jason A. Skinner,Robert J. Wilkinson,Robert J. Wilkinson,Robert J. Wilkinson,Charles T. Quinn,Derek Blankenship,Ranju Dhawan,John J. Cush,Asuncion Mejias,Octavio Ramilo,Onn Min Kon,Virginia Pascual,Jacques Banchereau,Damien Chaussabel,Anne O'Garra +24 more
TL;DR: A hitherto underappreciated role of type I IFN-αβ signalling in the pathogenesis of TB is demonstrated, which has implications for vaccine and therapeutic development and a broad range of transcriptional biomarkers with potential as diagnostic and prognostic tools to combat the TB epidemic are provided.
Journal ArticleDOI
Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion
Rimpei Morita,Nathalie Schmitt,Salah Eddine Bentebibel,Rajaram Ranganathan,Laure Bourdery,Gerard Zurawski,Gerard Zurawski,Emile Foucat,Melissa Dullaers,Sangkon Oh,Sangkon Oh,Natalie Sabzghabaei,Elizabeth M. Lavecchio,Marilynn Punaro,Marilynn Punaro,Virginia Pascual,Virginia Pascual,Jacques Banchereau,Jacques Banchereau,Jacques Banchereau,Hideki Ueno,Hideki Ueno +21 more
TL;DR: In this article, human blood CXCR5(+)CD4(+) T cells share functional properties with T follicular helper (Tfh) cells and appear to represent their circulating memory compartment.
Journal ArticleDOI
Induction of Dendritic Cell Differentiation by IFN-α in Systemic Lupus Erythematosus
Patrick Blanco,A. Karolina Palucka,Michelle A. Gill,Michelle A. Gill,Virginia Pascual,Virginia Pascual,Jacques Banchereau +6 more
TL;DR: The capacity of SLE patients' serum to induce DC differentiation correlated with disease activity and depended on the actions of interferon-α (IFN-α), suggesting unabated induction of DCs by IFN- α may drive the autoimmune response in SLE.
Journal ArticleDOI
Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus
Gina S. Garcia-Romo,Simone Caielli,Barbara Vega,John E. Connolly,Florence Allantaz,Zhaohui Xu,Marilynn Punaro,Marilynn Punaro,Jeanine Baisch,Cristiana Guiducci,Robert L. Coffman,Franck J. Barrat,Jacques Banchereau,Virginia Pascual,Virginia Pascual +14 more
TL;DR: An important role is shown for neutrophils in lupus pathogenesis, whereby neutrophil activated by anti-self antibodies release NETs, which contain antimicrobial peptides complexed with self-DNA and activate plasmacytoid dendritic cells, leading to interferon release and furtherment and aggravation of inflammation and disease.