J
J. Dinny Graham
Researcher at University of Sydney
Publications - 38
Citations - 2350
J. Dinny Graham is an academic researcher from University of Sydney. The author has contributed to research in topics: Progesterone receptor & Breast cancer. The author has an hindex of 18, co-authored 36 publications receiving 2103 citations. Previous affiliations of J. Dinny Graham include Children's Medical Research Institute & University of Colorado Hospital.
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Journal ArticleDOI
Physiological action of progesterone in target tissues.
TL;DR: Progesterone effects on proliferation and decidualization in the uterus during the menstrual cycle, and effects on lactation and Bone VIII.
Journal ArticleDOI
Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression.
TL;DR: A large family of coregulators is described and the range of proteins known to bind PR exceeds the complement required for transcriptional activation, suggesting that in the human, tissue-specific coregulator expression may modulate progesterone response.
Journal ArticleDOI
DNA replication licensing and progenitor numbers are increased by progesterone in normal human breast.
J. Dinny Graham,J. Dinny Graham,Patricia A. Mote,Patricia A. Mote,Usha Salagame,Usha Salagame,Jessica H. van Dijk,Rosemary L. Balleine,Rosemary L. Balleine,Lily I. Huschtscha,Lily I. Huschtscha,Roger R. Reddel,Roger R. Reddel,Christine L. Clarke,Christine L. Clarke +14 more
TL;DR: It is demonstrated that progesterone augments proliferation of normal human breast cells by both activating DNA replication licensing and kinetochore formation and increasing bipotent progenitor numbers.
Journal ArticleDOI
Altered Progesterone Receptor Isoform Expression Remodels Progestin Responsiveness of Breast Cancer Cells
J. Dinny Graham,Melissa L. Yager,Hazel D. Hill,Karen Byth,Geraldine M. O'Neill,Christine L. Clarke +5 more
TL;DR: It is suggested that disrupted balance of PRA and PRB remodels progestin responsiveness and that altered regulation of morphology and adhesion are important components of altered progest in response in breast cancer.
Journal ArticleDOI
Progesterone receptors - animal models and cell signaling in breast cancer Expression and transcriptional activity of progesterone receptor A and progesterone receptor B in mammalian cells
TL;DR: This work reviews the mammalian transcriptional studies of PRA and PRB, and compares them with what is known about their expression and function in target tissues, and concludes that the basis of these differences is yet to be fully understood.