Physiological action of progesterone in target tissues.
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Progesterone effects on proliferation and decidualization in the uterus during the menstrual cycle, and effects on lactation and Bone VIII.Abstract:
I. Introduction II. Synthesis and Secretion of Progesterone III. The Progesterone Receptor A. PR expression and regulation IV. Progesterone Regulation of Gene Expression in the Uterus, Ovary, and Chick Oviduct A. Progesterone effects on proliferation and decidualization in the uterus during the menstrual cycle B. Progesterone regulation of insulin-like growth factor (IGF) pathways in the endometrium C. Control of ovulation D. Implantation, uterine proliferation, and early pregnancy E. Myometrial contractility F. Chick oviduct V. Progesterone Action in the Breast A. Effect of progesterone on proliferation of the normal breast B. Progesterone regulation of genes associated with cell cycle progression C. Progesterone regulation of growth factors and growth factor receptors in the breast D. Markers of progestin action in the breast E. Progesterone effects on lactation VI. Progesterone Effects in the Brain VII. Progesterone Effects on Bone VIII. Antiestrogen Action of Progesterone A. Inhibition of ER expressio...read more
Citations
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Estrogen receptor null mice: what have we learned and where will they lead us?
John F. Couse,Kenneth S. Korach +1 more
TL;DR: The recent successful generation of double knockout, or alpha beta ERKO mice of both sexes, suggests that this receptor is also not essential to survival and was most likely not a compensatory factor in the survival of the alpha ERKO.
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Subgroup of Reproductive Functions of Progesterone Mediated by Progesterone Receptor-B Isoform
Biserka Mulac-Jericevic,Robert A. Mullinax,Francesco J. DeMayo,John P. Lydon,Orla M. Conneely +4 more
TL;DR: Progesterone receptors PR-A and PR-B are functionally distinct mediators of progesterone action in vivo and should provide suitable targets for generation of tissue-selective progestins.
Journal ArticleDOI
Progesterone induces adult mammary stem cell expansion
Purna A. Joshi,Hartland W. Jackson,Alexander G. Beristain,Marco A. Di Grappa,Patricia A. Mote,Christine L. Clarke,John Stingl,Paul Waterhouse,Rama Khokha +8 more
TL;DR: It is shown that the MaSC pool increases 14-fold during maximal progesterone levels at the luteal dioestrus phase of the mouse, demonstrating a key role for progester one in propelling this expansion.
Journal ArticleDOI
Classification and pharmacology of progestins.
Adolf E. Schindler,Carlo Campagnoli,René Druckmann,Johannes C. Huber,Jorge R. Pasqualini,K.-W. Schweppe,Jos H.H. Thijssen +6 more
TL;DR: Besides the natural progestin, progesterone, there are different classes of progestins, such as retroprogesterone, which need to be metabolized to become active compounds and have to be taken into account when medical treatment is considered.
Journal ArticleDOI
Unequal risks for breast cancer associated with different hormone replacement therapies: results from the E3N cohort study
TL;DR: The findings suggest that the choice of the progestagen component in combined HRT is of importance regarding breast cancer risk; it could be preferable to use progesterone or dydrogesterone.
References
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