J
J. Douglas Mitchell
Researcher at University of Central Lancashire
Publications - 5
Citations - 2612
J. Douglas Mitchell is an academic researcher from University of Central Lancashire. The author has contributed to research in topics: Motor neurone disease & Transthyretin. The author has an hindex of 4, co-authored 4 publications receiving 2385 citations.
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Journal ArticleDOI
TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
Jemeen Sreedharan,Ian P. Blair,Vineeta B. Tripathi,Xun Hu,Caroline Vance,Boris Rogelj,Steven Ackerley,Steven Ackerley,Jennifer C Durnall,Kelly L. Williams,Emanuele Buratti,Francisco E. Baralle,Jacqueline de Belleroche,J. Douglas Mitchell,P. Nigel Leigh,Ammar Al-Chalabi,Christopher C.J. Miller,Christopher C.J. Miller,Garth A. Nicholson,Garth A. Nicholson,Christopher Shaw +20 more
TL;DR: The evidence suggests a pathophysiological link between TDP-43 and ALS, and neighboring mutations in a highly conserved region of TARDBP in sporadic and familial ALS cases.
Journal ArticleDOI
Patients' health-related quality of life and utilities associated with different stages of amyotrophic lateral sclerosis.
Gwendoline M Kiebert,Colin Green,Caroline Murphy,J. Douglas Mitchell,Mary O'Brien,Anita Burrell,P. Nigel Leigh +6 more
TL;DR: The results from the ALSAQ-40 and EQ-5D descriptive system indicate that patients' HRQL decreases systematically with increasing severity of disease.
Journal ArticleDOI
Preliminary results of proton magnetic resonance spectroscopy in motor neurone disease (amytrophic lateral sclerosis)
Andrew P. Jones,Windsor J. Gunawardena,Christopher M.A. Coutinho,John A. Gatt,Ian C. Shaw,J. Douglas Mitchell +5 more
TL;DR: Possible changes in brain metabolites in motor neurone disease/amytrophic lateral sclerosis (MND/ALS) were investigated using 1H magnetic resonance spectroscopy and it could form a useful method for monitoring the effects of future trial treatment regimens.
Journal ArticleDOI
Social services homecare for people with motor neurone disease/amyotrophic lateral sclerosis: why are such services used or refused?
TL;DR: Qualitative findings revealed a number of barriers delaying the uptake of social services homecare in MND/ALS, including limited understanding of the disease amongst service providers and lack of awareness of service entitlement amongst patients and carers.
Journal ArticleDOI
Redefining Prognosis of Transthyretin Cardiomyopathy in the Tafamadis Era.
TL;DR: Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive and debilitative disease with a historically poor prognosis as mentioned in this paper .