Journal ArticleDOI
Preliminary results of proton magnetic resonance spectroscopy in motor neurone disease (amytrophic lateral sclerosis)
Andrew P. Jones,Windsor J. Gunawardena,Christopher M.A. Coutinho,John A. Gatt,Ian C. Shaw,J. Douglas Mitchell +5 more
TLDR
Possible changes in brain metabolites in motor neurone disease/amytrophic lateral sclerosis (MND/ALS) were investigated using 1H magnetic resonance spectroscopy and it could form a useful method for monitoring the effects of future trial treatment regimens.About:
This article is published in Journal of the Neurological Sciences.The article was published on 1995-05-01. It has received 63 citations till now. The article focuses on the topics: Motor neurone disease.read more
Citations
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Journal ArticleDOI
Biomarkers in amyotrophic lateral sclerosis.
TL;DR: Potential biomarkers that are sensitive to the progression of disease, which might enhance the diagnostic algorithm and provide new drug targets, are now being identified from analysis of the blood and cerebrospinal fluid, as well as from neuroimaging and neurophysiology studies.
Journal ArticleDOI
Diffusion tensor MRI assesses corticospinal tract damage in ALS
C M Ellis,Andrew Simmons,Derek K. Jones,Jeremy D.P. Bland,J M Dawson,Mark A. Horsfield,Steven Williams,Peter Leigh +7 more
TL;DR: The use of diffusion tensor MRI in detecting pathology of the corticospinal tracts in ALS supports the hypothesis that degeneration of the motor fibers in ALS would be reflected by changes in the diffusion characteristics of the white matter fibers in the posterior limb of the internal capsule.
Journal ArticleDOI
Neuroimaging in amyotrophic lateral sclerosis.
TL;DR: This comprehensive review considers the full range of neuroimaging techniques applied to amyotrophic lateral sclerosis over the last 25 years, the biomarkers they have revealed and future developments.
Journal Article
MR imaging and localized proton spectroscopy of the precentral gyrus in amyotrophic lateral sclerosis.
Brian C. Bowen,Pradip M. Pattany,Walter G. Bradley,James B. Murdoch,Francisco T Rotta,Akmal A. Younis,Robert C. Duncan,Robert M. Quencer +7 more
TL;DR: Mean metabolite concentrations determined from precentral gyrus spectra reflect clinical and pathologic changes that occur in ALS.
Journal ArticleDOI
The syndromes of frontotemporal dysfunction in amyotrophic lateral sclerosis.
TL;DR: There is good correlation between the presence of a syndrome of frontotemporal dysfunction and alterations in brain structure or function as identified with a wide variety of neuroimaging techniques and which reflect a frontotmporal lobar degeneration (FTLD).
References
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Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies
TL;DR: Immunocytochemical staining has shown that N-acetyl-aspartate-like immunoreactivity is localized in neurons, which are widely distributed throughout the brain.
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Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: Assessment of the load of disease
TL;DR: Spectra obtained from affected brain in patients with multiple sclerosis revealed a decreased ratio of N‐acetylaspartate to creatine resonance intensities, and it is proposed that the observed metabolite changes can be useful as an index of irreversible CNS injury.
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On the identification of cerebral metabolites in localized 1H NMR spectra of human brain In vivo
Thomas Michaelis,Klaus-Dietmar Merboldt,Wolfgang Hänicke,Michael L. Gyngell,Harald Bruhn,Jens Frahm +5 more
TL;DR: The assignment of 1H NMR resonances of cerebral metabolites under the experimental conditions used for human investigations shows enhanced levels of cerebral glutamine detected in patients with liver cirrhosis, and for the first time elevated levels of brain glucose are observed in Patients with diabetes mellitus.
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Localized in vivo proton spectroscopy in the brain of patients with multiple sclerosis.
H. B. W. Larsson,P. Christiansen,Mikael Jensen,Jette L. Frederiksen,Anne Heltberg,Jes Olesen,Otto M. Henriksen +6 more
TL;DR: MR spectroscopic demonstration of lipids in a MS plaque probably reflects disintegration of myelin, and a decreased NAA/Cho ratio may be related either to gliosis or to axonal degeneration, which sometimes occurs in longstanding MS.
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Correlation of spectroscopy and magnetization transfer imaging in the evaluation of demyelinating lesions and normal appearing white matter in multiple sclerosis
John F. Hiehle,Robert E. Lenkinski,Robert I. Grossman,Vincent Dousset,Karen N. Ramer,Mitchell D. Schnall,Jeffrey A. Cohen,Francisco Gonzalez-Scarano +7 more
TL;DR: Increased resonance peaks in the 2.1 to 2.6 ppm range and marked decreases in MTR may be a relatively specific indicators of demyelination in multiple sclerosis patients.