J
J. F. Garcia-Lazaro
Researcher at University of Mainz
Publications - 4
Citations - 245
J. F. Garcia-Lazaro is an academic researcher from University of Mainz. The author has contributed to research in topics: Transgene & Confocal. The author has an hindex of 3, co-authored 4 publications receiving 231 citations.
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Journal ArticleDOI
Liver fibrosis induced by hepatic overexpression of PDGF-B in transgenic mice
P. Czochra,Borut Klopcic,E. Meyer,Johannes Herkel,J. F. Garcia-Lazaro,Florian Thieringer,Peter Schirmacher,Stefan Biesterfeld,Peter R. Galle,Ansgar W. Lohse,Stephan Kanzler +10 more
TL;DR: PDGF-B was identified as a proliferative and profibrogenic stimulus and potential inducer of stellate cell transdifferentiation in vivo and causes liver fibrosis without significantly upregulating TGF-beta1, suggesting a T GF-beta-independent mechanism.
Journal ArticleDOI
MORT1/FADD is involved in liver regeneration.
Marcus Schuchmann,Felix Rückert,J. F. Garcia-Lazaro,Andrea Karg,Jürgen Burg,Natalia Knorr,Jürgen Siebler,Eugene Varfolomeev,David Wallach,Wolfgang Schreiber,Ansgar W. Lohse,Peter R. Galle +11 more
TL;DR: The data demonstrate for the first time an involvement of the death receptor molecule MORT1/FADD in liver regeneration, beyond its well described role as part of the intracellular death signaling pathway.
Journal ArticleDOI
610 Anti IL-6 therapy rescues transgenic mice with liver specific overexpression of TGF-β1 from death after LPS mediated liver injury
Florian Thieringer,J. F. Garcia-Lazaro,P. Czochra,U. Schmitt,D. Friebe,E. Meyer,Stefan Lüth,M. Schuchmann,Peter R. Galle,AW Lohse +9 more
Proceedings ArticleDOI
In vivo molecular and morphological imaging by real time confocal mini-microscopy
Martin Goetz,Sebastian Gregor,Christian Fottner,J. F. Garcia-Lazaro,Esther Schirrmacher,Oliver Kempski,Peter Bartenstein,Mathias Weber,Stefan Biesterfeld,Peter R. Galle,Markus F. Neurath,Ralf Kiesslich +11 more
TL;DR: The newly developed miniaturized confocal laser microscopy probe allows real time in vivo molecular and morphological histologic imaging at high resolution of normal and diseased tissue in rodents and will have a high impact on different faculties in medicine.