Journal ArticleDOI
Liver fibrosis induced by hepatic overexpression of PDGF-B in transgenic mice
P. Czochra,Borut Klopcic,E. Meyer,Johannes Herkel,J. F. Garcia-Lazaro,Florian Thieringer,Peter Schirmacher,Stefan Biesterfeld,Peter R. Galle,Ansgar W. Lohse,Stephan Kanzler +10 more
TLDR
PDGF-B was identified as a proliferative and profibrogenic stimulus and potential inducer of stellate cell transdifferentiation in vivo and causes liver fibrosis without significantly upregulating TGF-beta1, suggesting a T GF-beta-independent mechanism.About:
This article is published in Journal of Hepatology.The article was published on 2006-09-01. It has received 215 citations till now. The article focuses on the topics: Hepatic stellate cell & Hepatic fibrosis.read more
Citations
More filters
Journal ArticleDOI
Mechanisms of Hepatic Fibrogenesis
TL;DR: Clinical and translational implications of these advances have become clear, and have begun to impact significantly on the management and outlook of patients with chronic liver disease.
Journal ArticleDOI
Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
TL;DR: The hepatic stellate cell has surprised and engaged physiologists, pathologists, and hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis only emerged following the refinement of methods for its isolation and characterization.
Journal ArticleDOI
Hepatic stellate cells as key target in liver fibrosis
TL;DR: Cell type- and target-specific pharmacological intervention to therapeutically induce the deactivation of hepatic stellate cells will enable more effective and less toxic precision antifibrotic therapies.
Journal ArticleDOI
Liver inflammation and fibrosis
Yukinori Koyama,David A. Brenner +1 more
TL;DR: The initiation of inflammation in the liver, the liver inflammatory cells, and their crosstalk with myofibroblasts are reviewed.
Journal ArticleDOI
Stromal myofibroblasts are drivers of invasive cancer growth.
TL;DR: Fibrosis is a major side effect of radiotherapy, and the question how the main methods of cancer management, including chemotherapy, hormonotherapy and surgery affect myofibroblasts and by inference the surrogate endpoints invasion and metastasis is addressed.
References
More filters
Book
A Laboratory manual
TL;DR: To develop a program to print the barcodes using two commonly uses command sets and hence evaluates their ease of use for such applications, students should be able to program dot matrix printers, by manipulating bit level information and ink jet printers using page description language, such as PCL.
Journal ArticleDOI
Genomic sequencing
George M. Church,Walter Gilbert +1 more
TL;DR: The genomic sequencing procedures are applicable to the analysis of genetic polymorphisms, DNA methylation at deoxycytidines, and nucleic acid-protein interactions at single nucleotide resolution.
Book
Manipulating the mouse embryo: A laboratory manual
TL;DR: Here are recorded the tech- niques for preparing, inserting and analysing DNA sequences, for retroviral infection of mice, for production and use of EC and EK cells as vehicles for engineered sequences and for nuclear transplantation - all against a background of the basic procedures required for pro- ducing and handling the em- bryos.
Journal Article
A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples.
TL;DR: The complete recovery of DNA from samples used for the RNA and protein isolation makes it possible to normalize the results of gene expression studies based on DNA content instead of on the more variable total RNA, protein content or tissue weight.