J
J.F. Rumigny
Researcher at French Institute of Health and Medical Research
Publications - 14
Citations - 627
J.F. Rumigny is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: NCS-382 & GHB receptor. The author has an hindex of 11, co-authored 14 publications receiving 626 citations. Previous affiliations of J.F. Rumigny include Centre national de la recherche scientifique.
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Journal ArticleDOI
High affinity binding site for γ-hydroxybutyric acid in rat brain
J. Benavides,J.F. Rumigny,Jean-Jacques Bourguignon,C. Cash,Camille-Georges Wermuth,Paul Mandel,Guy Vincendon,Michel Maitre +7 more
TL;DR: In this article, the presence of a high affinity, apparently specific binding site for γ-hydroxybutyric acid (GHB) in the same tissue has been demonstrated and the binding does not require Na + and takes place optimally at pH 5.5.
Journal ArticleDOI
A high-affinity, Na+-dependent uptake system for gamma-hydroxybutyrate in membrane vesicles prepared from rat brain.
J. Benavides,J.F. Rumigny,Jean-Jacques Bourguignon,Camille-Georges Wermuth,Paul Mandel,Michel Maitre +5 more
TL;DR: A series of related compounds, including aryl‐or alkyl‐derivatives, has been examined for ability to inhibit GHB uptake, indicative of its possible physiological role and also of the existence of a high‐affinity uptake system for GHB.
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Specific and non‐specific succinic semialdehyde reductases from rat brain: Isolation and properties
Journal ArticleDOI
Regional and Subcellular Localization in Rat Brain of the Enzymes That Can Synthesize γ‐Hydroxybutyric Acid
TL;DR: Rat brain contains two major NADPH‐linked aldehyde reductases that can reduce succinate semialdehyde to 4‐hydroxybutyrate and these enzymes are mainly cytoplasmic but there is some activity in the synaptosomal fraction.
Journal ArticleDOI
A m3 muscarinic receptor coupled to inositol phosphate formation in the rat cochlea
Janique Guiramand,Ebrahim Mayat,Sylvain Bartolami,Marc Lenoir,J.F. Rumigny,Rémy Pujol,Max Récasens +6 more
TL;DR: The pharmacological profile suggests that the activation of the M3 muscarinic receptor subtype is responsible for the increase in IPs synthesis in the rat cochlea, as opposed to the usual existence of several receptors coupled to this transduction system in other organs such as the brain.