Marc Lenoir

TL;DR: It is concluded that deafness in Slc17a8-deficient mice is due to a specific defect of vesicular glutamate uptake and release and that VGLUT3 is essential for auditory coding at the IHC synapse.

TL;DR: Sound-evoked compound action potential (CAP) is commonly used to probe deafness in experimental and clinical settings as discussed by the authors, which captures the synchronous activation of the auditory nerve fibers.

TL;DR: The injection of artificial classical Konishi perilymph with KA confirmed the strong difference between afferents innervating the IHCs and the OHCs in adult cochleas and shed some light on the synaptic plasticity found at the O HC level during synaptogenesis.

TL;DR: The results provide evidence that targeting oxidative stress, chronic inflammation, or apoptotic pathways may have therapeutic potential and the fact that autophagic stress and protein aggregation occurred specifically in SGNs also offers promising perspectives for the prevention of neural presbycusis.

TL;DR: The first morphological and ultrastructural evidence of massive acoustic trauma, not compatible with life, is presented in four cephalopod species subjected to low-frequency controlled-exposure experiments, indicating a need for further environmental regulation of human activities that introduce high-intensity, low- frequencies in the world's oceans.