J
J Fryer
Publications - 2
Citations - 1414
J Fryer is an academic researcher. The author has contributed to research in topics: Bolus (medicine) & Performance status. The author has an hindex of 2, co-authored 2 publications receiving 1378 citations.
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Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer.
Pascal Piedbois,Ph. Rougier,Marc Buyse,J.P. Pignon,Louise Ryan,R Hansen,Benny Zee,B Weinerman,J Pater,Cynthia G. Leichman,John S. Macdonald,Jacqueline Benedetti,J Lokich,J Fryer,G Brufman,R Isacson,Agnès Laplanche,E Levy +17 more
TL;DR: 5-FU CI is superior to 5-FU bolus in terms of tumor response and achieves a slight increase of overall survival, and the hematologic toxicity is much less important in patients who receive 5-fu CI, but hand-foot syndrome is frequent in this group of patients.
Journal ArticleDOI
Toxicity of fluorouracil in patients with advanced colorectal cancer: effect of administration schedule and prognostic factors.
E Levy,Pascal Piedbois,Marc Buyse,J.P. Pignon,Ph. Rougier,Louise Ryan,R Hansen,Benny Zee,B Weinerman,J Pater,Cynthia G. Leichman,John S. Macdonald,Jacqueline Benedetti,J Lokich,J Fryer,G Brufman,R Isacson,Agnès Laplanche,E. Quinaux,Pierre Thirion +19 more
TL;DR: Based on a large data set, the toxicity profile of the two schedules of administration of 5-FU was confirmed and quantified and allowed the identification of clinical predictors of toxicity.