C
Cynthia G. Leichman
Researcher at New York University
Publications - 32
Citations - 3809
Cynthia G. Leichman is an academic researcher from New York University. The author has contributed to research in topics: Oxaliplatin & Colorectal cancer. The author has an hindex of 16, co-authored 32 publications receiving 3675 citations. Previous affiliations of Cynthia G. Leichman include Roswell Park Cancer Institute.
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Journal ArticleDOI
Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer.
Pascal Piedbois,Ph. Rougier,Marc Buyse,J.P. Pignon,Louise Ryan,R Hansen,Benny Zee,B Weinerman,J Pater,Cynthia G. Leichman,John S. Macdonald,Jacqueline Benedetti,J Lokich,J Fryer,G Brufman,R Isacson,Agnès Laplanche,E Levy +17 more
TL;DR: 5-FU CI is superior to 5-FU bolus in terms of tumor response and achieves a slight increase of overall survival, and the hematologic toxicity is much less important in patients who receive 5-fu CI, but hand-foot syndrome is frequent in this group of patients.
Journal Article
Thymidylate Synthase Gene and Protein Expression Correlate and Are Associated with Response to 5-Fluorouracil in Human Colorectal and Gastric Tumors
Patrick G. Johnston,Heinz-Josef Lenz,Cynthia G. Leichman,Kathleen D. Danenberg,Carmen J. Allegra,Peter V. Danenberg,Lawrence Leichman +6 more
TL;DR: TS protein and TS mRNA expression are highly correlated, and each predict for response to 5-FU/LV-based chemotherapy in patients with colorectal and gastric cancer.
Journal ArticleDOI
ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy.
Ralf Metzger,Cynthia G. Leichman,Kathleen D. Danenberg,Peter V. Danenberg,Heinz-Josef Lenz,K. Hayashi,Susan Groshen,Dennis Salonga,Hartley Cohen,Loren Laine,Peter F. Crookes,Howard Silberman,Joaquina Baranda,Brahma Konda,Lawrence Leichman +14 more
TL;DR: Either ERCC1 or TS mRNA levels in a primary gastric adenocarcinoma has a statistically significant relationship to response; in this cohort TS RNA levels did not reach statistically significant association with survival as in the previous publication.
Journal ArticleDOI
Toxicity of fluorouracil in patients with advanced colorectal cancer: effect of administration schedule and prognostic factors.
E Levy,Pascal Piedbois,Marc Buyse,J.P. Pignon,Ph. Rougier,Louise Ryan,R Hansen,Benny Zee,B Weinerman,J Pater,Cynthia G. Leichman,John S. Macdonald,Jacqueline Benedetti,J Lokich,J Fryer,G Brufman,R Isacson,Agnès Laplanche,E. Quinaux,Pierre Thirion +19 more
TL;DR: Based on a large data set, the toxicity profile of the two schedules of administration of 5-FU was confirmed and quantified and allowed the identification of clinical predictors of toxicity.
Journal ArticleDOI
Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival.
Heinz-Josef Lenz,Cynthia G. Leichman,Kathleen D. Danenberg,Peter V. Danenberg,Susan Groshen,Hartley Cohen,Loren Laine,Peter F. Crookes,Howard Silberman,Joaquina Baranda,Yolee Garcia,James Li,Lawrence Leichman +12 more
TL;DR: The genetic expression of TS (TSmRNA level) influences response to 5FU-based chemotherapy and survival for a cohort of patients with primary gastric cancer, and could lead to therapeutic decisions based on specific molecular properties within a tumor.