J
J. J. A. Holden
Researcher at Queen's University
Publications - 41
Citations - 1611
J. J. A. Holden is an academic researcher from Queen's University. The author has contributed to research in topics: Locus (genetics) & Gene mapping. The author has an hindex of 20, co-authored 41 publications receiving 1581 citations. Previous affiliations of J. J. A. Holden include St. Michael's Hospital & Kingston General Hospital.
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Journal ArticleDOI
Assignment of multiple endocrine neoplasia type 2A to chromosome 10 by linkage
N. E. Simpson,Kenneth K. Kidd,Paul J. Goodfellow,McDermid He,Shirley M. Myers,J.R. Kidd,Charles E. Jackson,Alessandra M.V. Duncan,Lindsay A. Farrer,K. Brasch,Carmela M. Castiglione,Myron Genel,Joseph M. Gertner,C. R. Greenberg,James F. Gusella,J. J. A. Holden,Bradley N. White +16 more
TL;DR: The MEN2A locus was assigned to chromosome 10 by linkage with a new DNA marker (D10S5) and the linkage led to investigate other chromosome 10 markers and demonstrate linkage between the disease locus and the interstitial retinol-binding protein (IRBP) gene1.
Journal ArticleDOI
Association of autism severity with a monoamine oxidase A functional polymorphism.
Ira L. Cohen,Xudong Liu,Chris K. Schutz,Bradley N. White,Edmund C. Jenkins,W. T. Brown,J. J. A. Holden +6 more
TL;DR: It is concluded that functional MAOA‐uVNTR alleles may act as a genetic modifier of the severity of autism in males.
Journal ArticleDOI
Characterization of the supernumerary chromosome in cat eye syndrome.
McDermid He,Alessandra M.V. Duncan,K. Brasch,J. J. A. Holden,Ellen Magenis,R Sheehy,John Burn,Nataline Kardon,Bernard Noel,Albert Schinzel,Ikuko Teshima,Bradley N. White +11 more
TL;DR: This work demonstrates how DNA sequence dosage analysis can be used to study genetic disorders that are not readily amenable to standard cytogenetic analysis.
Journal ArticleDOI
Clinical and molecular cytogenetic characterisation of a newly recognised microdeletion syndrome involving 2p15-16.1
E. Rajcan-Separovic,Chansonette Harvard,X Liu,Barbara McGillivray,J G Hall,Ying Qiao,Jane Hurlburt,J Hildebrand,Elizabeth C. R. Mickelson,J. J. A. Holden,M. E. S. Lewis +10 more
TL;DR: The common constellation of features found in the two affected subjects indicates that they have a newly recognised microdeletion syndrome involving haploinsufficiency of one or more genes deleted within at least a 4.5-Mb segment of the 2p15-16.1 region.
Journal ArticleDOI
A gene family in Drosophila melanogaster coding for trypsin-like enzymes
TL;DR: The sequence further strengthens the hypothesis that the chymotrypsin cleavage specificity developed separately in the vertebrates and invertebrates.