J. Lacau St Guily

TL;DR: These main approaches to de‐escalate treatment in HPV‐positive OPSCC are reviewed, the rationale behind them are discussed, and the issues raised by treatment de-escalation are discussed.

TL;DR: It is demonstrated that, in contrast to the oropharynx, only a small fraction of cancers located in the oral cavity seem to be HPV-related even in young non-smoking non-drinking patients.

TL;DR: High-risk human papillomavirus, particularly type 16, is now recognised as a causative agent in a subset of oropharyngeal squamous cell carcinomas, raising the question of de escalation therapy to reduce long term consequences in a younger cohort of patients with a long life expectancy.

TL;DR: FET did not appear to be suited as a first-line PET tracer in HNSCC imaging and cannot replace FDG for staging due to insufficient sensitivity, but was useful in a few selected cases to favor a wait and see attitude when a FDG+ FET− focus was discovered.

TL;DR: Results indicate that real-time RT–PCR assay for the detection of CK19 mRNA is a sensitive and reliable method for the Detection of carcinomatous cells in lymph nodes.