J. Menissier De Murcia

TL;DR: It is reported that mice carrying a targeted disruption of the PARP‐2 gene are sensitive to ionizing radiation, and specific female embryonic lethality is observed in parp‐1+/−parp‐2−/− mutants at E9.5.

TL;DR: Cl cloning and expression in Escherichia coli of a cDNA fragment encoding the two putative zinc fingers (FI and FII) domain of the human poly(ADP-ribose) polymerase is described, demonstrating that poly( ADP- ribose) polyase contains a type of zinc finger that differs from previously recognized classes in terms of both structure and function.

TL;DR: The crystal structures of the catalytic fragment of chicken poly(ADP-ribose) polymerase with and without a nicotinamide-analogue inhibitor have been elucidated, because this enzyme is involved in the regulation of DNA repair, its inhibitors are of interest for cancer therapy.

TL;DR: This article summarizes the present knowledge in this field of poly(ADP-ribose) polymerase and states that the structure and the function of this abundant and highly conserved enzyme are currently unknown.

TL;DR: The results presented here support the concept that the human PARP NLS is an autonomous functional element and belongs to the class of bipartite NLSs and the linear distance between the two basic clusters is not crucial.