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Aline Huber
Researcher at University of Strasbourg
Publications - 14
Citations - 2529
Aline Huber is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Poly ADP ribose polymerase & Retinoid X receptor. The author has an hindex of 9, co-authored 14 publications receiving 2327 citations. Previous affiliations of Aline Huber include École Normale Supérieure.
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Journal ArticleDOI
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
Péter Bai,Péter Bai,Carles Cantó,Hugues Oudart,Attila Brunyanszki,Yana Cen,Charles Thomas,Hiroyasu Yamamoto,Aline Huber,Borbála Kiss,Riekelt H. Houtkooper,Kristina Schoonjans,Valérie Schreiber,Anthony A. Sauve,Josiane Ménissier-de Murcia,Johan Auwerx +15 more
TL;DR: The deletion of the poly(ADP-ribose) polymerase-1 (PARP-1) gene, encoding a major NAD(+)-consuming enzyme, increases NAD(+) content and SIRT1 activity in brown adipose tissue and muscle and the pharmacologic inhibition of PARP in vitro and in vivo is shown.
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Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse
Josiane Ménissier-de Murcia,Michelle Ricoul,Laurence Tartier,Claude Niedergang,Aline Huber,Françoise Dantzer,Valérie Schreiber,Jean-Christophe Amé,Andrée Dierich,Marianne LeMeur,Laure Sabatier,Pierre Chambon,Gilbert de Murcia +12 more
TL;DR: The DNA damage-dependent poly(ADP-ribose) polymerases, PARP1 and PARP-2, homo-and heterodimerize and are both involved in the base excision repair (BER) pathway as mentioned in this paper.
Journal Article
Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse
J. Menissier De Murcia,Michelle Ricoul,Aline Huber,Claude Niedergang,Valérie Schreiber,Laure Sabatier,G. de Murcia +6 more
TL;DR: It is reported that mice carrying a targeted disruption of the PARP‐2 gene are sensitive to ionizing radiation, and specific female embryonic lethality is observed in parp‐1+/−parp‐2−/− mutants at E9.5.
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PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure
Péter Bai,Péter Bai,Carles Cantó,Attila Brunyanszki,Aline Huber,Magdolna Szántó,Yana Cen,Hiroyasu Yamamoto,Sander M. Houten,Borbála Kiss,Borbála Kiss,Hugues Oudart,Pál Gergely,Josiane Ménissier-de Murcia,Valérie Schreiber,Anthony A. Sauve,Johan Auwerx +16 more
TL;DR: The results indicate that PARP-2 deficiency increases SIRT1 activity in cultured myotubes, however, this increase was not due to changes in NAD(+) levels, but to an increase in SIRT 1 expression, as PARp-2 acts as a direct negative regulator of the SIRT2 promoter.
Journal ArticleDOI
PARP-1, PARP-2 and ATM in the DNA damage response: functional synergy in mouse development
TL;DR: This review summarizes the present knowledge on their physiological role in the cellular response to DNA damage and on the genetic interactions between PARP-1,PARP-2, Atm that play an essential role during early embryogenesis.