J
J. R. Thistlethwaite
Researcher at Johnson & Johnson
Publications - 1
Citations - 233
J. R. Thistlethwaite is an academic researcher from Johnson & Johnson. The author has contributed to research in topics: CD3 & Antibody. The author has an hindex of 1, co-authored 1 publications receiving 226 citations.
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A non-activating "humanized" anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo.
Maria-Luisa Alegre,L. J. Peterson,Danlin Xu,Husain Sattar,D R Jeyarajah,K. Kowalkowski,J. R. Thistlethwaite,R. A. Zivin,L K Jolliffe,Jeffrey A. Bluestone,Jeffrey A. Bluestone +10 more
TL;DR: An experimental model in which human splenocytes from cadaveric organ donors were inoculated into severe combined immunodeficient mice to test the activating and immunosuppressive properties of these anti-human CD3 mAbs in vivo suggests the use of an Fc variant in clinical transplantation should result in fewer side effects than observed with OKT3, while maintaining its clinical efficacy.