M
Maria-Luisa Alegre
Researcher at University of Chicago
Publications - 206
Citations - 17360
Maria-Luisa Alegre is an academic researcher from University of Chicago. The author has contributed to research in topics: Transplantation & T cell. The author has an hindex of 54, co-authored 194 publications receiving 14704 citations. Previous affiliations of Maria-Luisa Alegre include University of California, San Diego & Washington University in St. Louis.
Papers
More filters
Journal ArticleDOI
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy
Ayelet Sivan,Leticia Corrales,Nathaniel Hubert,Jason B. Williams,Keston Aquino-Michaels,Zachary M. Earley,Franco W. Benyamin,Yuk Man Lei,Bana Jabri,Maria-Luisa Alegre,Eugene B. Chang,Thomas F. Gajewski +11 more
TL;DR: Comparison of melanoma growth in mice harboring distinct commensal microbiota and observed differences in spontaneous antitumor immunity, suggests that manipulating the microbiota may modulate cancer immunotherapy.
Journal ArticleDOI
The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients
Vyara Matson,Jessica Fessler,Riyue Bao,Tara Chongsuwat,Yuanyuan Zha,Maria-Luisa Alegre,Jason J. Luke,Thomas F. Gajewski +7 more
TL;DR: The results suggest that the commensal microbiome may have a mechanistic impact on antitumor immunity in human cancer patients and could lead to improved tumor control, augmented T cell responses, and greater efficacy of anti–PD-L1 therapy.
Journal ArticleDOI
Modulation of tryptophan catabolism by regulatory T cells.
Francesca Fallarino,Ursula Grohmann,Kwang Woo Hwang,Ciriana Orabona,Carmine Vacca,Roberta Bianchi,Maria Laura Belladonna,Maria C. Fioretti,Maria-Luisa Alegre,Paolo Puccetti +9 more
TL;DR: It is shown that mouse CD4+CD25+ cells, either resting or induced to overexpress CTLA-4 by treatment with antibody to CD3, initiated tryptophan catabolism in dendritic cells through a CT LA-4-dependent mechanism, which might represent a major mechanism of action of TR cells.
Journal ArticleDOI
STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors
Seng Ryong Woo,Mercedes Beatriz Fuertes,Leticia Corrales,Stefani Spranger,Michael J. Furdyna,Michael Y. K. Leung,Ryan Duggan,Ying Wang,Glen N. Barber,Katherine A. Fitzgerald,Maria-Luisa Alegre,Thomas F. Gajewski +11 more
TL;DR: It is found that spontaneous CD8(+) T cell priming against tumors was defective in mice lacking stimulator of interferon genes complex (STING), but not other innate signaling pathways, suggesting involvement of a cytosolic DNA sensing pathway.
Journal ArticleDOI
Serum Cytokine Levels in Human Septic Shock: Relation to Multiple-System Organ Failure and Mortality
Michael R. Pinsky,Jean Louis Vincent,Jacques Devière,Maria-Luisa Alegre,Robert J. Kahn,Etienne Dupont +5 more
TL;DR: TNF and IL-6 serum levels are higher in septic than in nonseptic shock, but the persistence of TNF andIL-6 in the serum rather than peak levels of cytokines predicts a poor outcome in patients with shock.