J. Rahman

TL;DR: In this paper , the authors identify positive regulators of T cell functions through overexpression of around 12,000 barcoded human open reading frames (ORFs), which increased the proliferation and activation of primary human CD4+ and CD8+ T cells and their secretion of key cytokines such as interleukin-2 and interferonγ.

TL;DR: In this article , the authors identify positive regulators of T cell functions through overexpression of around 12,000 barcoded human open reading frames (ORFs), which increased the proliferation and activation of primary human CD4+ and CD8+ T cells and their secretion of key cytokines such as interleukin-2 and interferonγ.

TL;DR: The viral communities in New York City (NYC) wastewater are profiled using metagenomic data collected in November 2014, showing that phages accounted for the largest viral component of the sewage samples and that specific virus communities were associated with local environmental conditions within boroughs.

TL;DR: In this paper, a function-first proteomic strategy that uses size exclusion chromatography (SEC) to assess the global impact of electrophilic compounds on protein complexes in human cells is described.

TL;DR: In this paper , the authors performed CRISPR-Cas9 screens across a broad range of therapies used in acute myeloid leukemia to identify genomic determinants of drug response, uncovering a selective dependency on RNA splicing factors whose loss preferentially enhances response to the BCL2 inhibitor venetoclax.