John R. Teijaro

TL;DR: A role for potent neutralizing antibodies (nAbs) in prophylaxis, and potentially therapy, of COVID-19 is suggested, as indicated by maintained weight and low lung viral titers in treated animals, and the passive transfer of a nAb provides protection against disease in high-dose SARS-CoV-2 challenge in Syrian hamsters.

TL;DR: A direct causal link between IFN-I signaling, immune activation, negative immune regulator expression, lymphoid tissue disorganization, and virus persistence is demonstrated and the results suggest that therapies targeting IFn-I may help control persistent virus infections.

TL;DR: It is demonstrated that suppression of early innate immune responses through S1P1 signaling results in reduced mortality during infection with a human pathogenic strain of influenza virus, suggesting that diseases in which amplification of cytokine storm is a significant pathological component could be chemically tractable.

TL;DR: A quantitative analysis of cysteine-reactive small-molecule fragments screened against thousands of proteins in human proteomes and cells provides a greatly expanded portrait of the ligandable proteome and furnishes compounds that can illuminate protein functions in native biological systems.

TL;DR: A new class of lung tissue-resident memory CD4 T cells that exhibit tissue tropism and retention independent of Ag or inflammation is identified, important for targeting local protective responses in vaccines and immunotherapies.