J. Reckweg

TL;DR: It is demonstrated that psilocybin induced region-dependent alterations in glutamate, which predicted distortions in the subjective experience of one’s self (ego dissolution), which may provide a neurochemical basis for therapeutic effects as witnessed in ongoing clinical trials.

TL;DR: In this paper, a double-blind, placebo-controlled, parallel-group design was used to investigate the effect of psilocybin on creativity and its effect on cognitive flexibility.

TL;DR: In this paper, a naturalistic observational study was designed to assess whether mental health changes were produced by ayahuasca or by set and setting, and the results suggest that improvements in mental health of participants of Ayahuasca ceremonies can be driven by non-pharmacological factors that constitute a placebo response but also by pharmacological factors related to the use of the drug.

TL;DR: The rapid onset and short duration of the 5‐MeO‐DMT experience may render it more suitable for individual dose‐finding strategies compared with longer‐acting psychedelics, which may contribute to changes in mental health outcomes.

TL;DR: In this paper, the authors investigated the acute effects of synthetic cannabinoids on cognitive and psychomotor tasks in participants who are demonstrating representative levels of acute intoxication, including motor coordination, attention, memory, speed-accuracy efficiency, and response speed.