J
J. Schölmerich
Researcher at University of Regensburg
Publications - 265
Citations - 10016
J. Schölmerich is an academic researcher from University of Regensburg. The author has contributed to research in topics: Colitis & Inflammatory bowel disease. The author has an hindex of 56, co-authored 265 publications receiving 9591 citations.
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Journal ArticleDOI
Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation
Martin Hausmann,Stephan Kiessling,S. Mestermann,G. Webb,T. Spöttl,T. Andus,J. Schölmerich,Hans H Herfarth,K. Ray,Werner Falk,Gerhard Rogler +10 more
TL;DR: This study shows the inflammation-dependent induction of TLR2 and TLR4 expression in intestinal macrophages and concludes that the absence of TLRs abolishes the reactivity of mucosal macrophage to bacterial wall products.
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Neutralization of tumour necrosis factor (TNF) but not of IL‐1 reduces inflammation in chronic dextran sulphate sodium‐induced colitis in mice
G. Kojouharoff,Wolfgang Hans,Florian Obermeier,Daniela N. Männel,T. Andus,J. Schölmerich,V. Gross,Werner Falk +7 more
TL;DR: It is concluded that in acute colitis IL‐1 and TNF are beneficial, whereas in chronic colitis, TNF but notIL‐1 seems to play a major role in perpetuation of chronic inflammation.
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Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue.
Andreas Schäffler,Markus Neumeier,Hans H Herfarth,Alois Fürst,J. Schölmerich,Christa Büchler +5 more
TL;DR: Omentin might be a new adipocytokine playing a role in the defense against intestinal bacterial translocation in the context of Crohn's disease.
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Interferon-gamma (IFN-gamma)- and tumour necrosis factor (TNF)-induced nitric oxide as toxic effector molecule in chronic dextran sulphate sodium (DSS)-induced colitis in mice.
TL;DR: TNF and IFN‐γ are involved in perpetuation of chronic DSS‐induced colitis, and induction of excessive nitric oxide activity could be their common effector mechanism.
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Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease.
TL;DR: Analysis of IL8 in mucosal biopsy specimens of patients with Crohn's disease and ulcerative colitis by enzyme linked immunosorbent assay (ELISA) and by in situ hybridisation found that IL8 mRNA was only detected in inflammatory cells of the interstitium but not in mucosa epithelial cells.