J
J. Timothy Greenamyre
Researcher at University of Pittsburgh
Publications - 165
Citations - 20052
J. Timothy Greenamyre is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Parkinson's disease & Neurodegeneration. The author has an hindex of 65, co-authored 160 publications receiving 18134 citations. Previous affiliations of J. Timothy Greenamyre include Veterans Health Administration & University of Texas Southwestern Medical Center.
Papers
More filters
Journal ArticleDOI
Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines
Alexander Panov,Claire-Anne Gutekunst,Blair R. Leavitt,Michael R. Hayden,James R. Burke,Warren J. Strittmatter,J. Timothy Greenamyre +6 more
TL;DR: It is shown that lymphoblast mitochondria from patients with HD have a lower membrane potential and depolarize at lower calcium loads than do mitochondriaFrom controls, and mitochondrial calcium abnormalities occur early in HD pathogenesis and may be a direct effect of mutant huntingtin on the organelle.
Journal ArticleDOI
Mechanism of toxicity in rotenone models of Parkinson's disease.
Todd B. Sherer,Ranjita Betarbet,Claudia M. Testa,Byoung Boo Seo,Jason R. Richardson,Jin Ho Kim,Gary W. Miller,Takao Yagi,Akemi Matsuno-Yagi,J. Timothy Greenamyre +9 more
TL;DR: The involvement of oxidative damage in rotenone toxicity is demonstrated and antioxidant therapies for Parkinson's disease are supported, using three model systems of increasing complexity.
Journal ArticleDOI
Subcutaneous Rotenone Exposure Causes Highly Selective Dopaminergic Degeneration and α-Synuclein Aggregation
TL;DR: It is demonstrated that chronic systemic exposure to the pesticide and mitochondrial toxin rotenone through jugular vein cannulation reproduced many features of Parkinson's disease in rats, including nigrostriatal dopaminergic degeneration and formation of alpha-synuclein-positive cytoplasmic inclusions in nigral neurons.
Journal ArticleDOI
A highly reproducible rotenone model of Parkinson's disease
Jason R. Cannon,Victor Tapias,Hye Mee Na,Anthony S. Honick,Robert E. Drolet,J. Timothy Greenamyre +5 more
TL;DR: This version of the rotenone model of Parkinson's disease is highly reproducible and may provide an excellent tool to test new neuroprotective strategies.
Journal ArticleDOI
An In Vitro Model of Parkinson's Disease: Linking Mitochondrial Impairment to Altered α-Synuclein Metabolism and Oxidative Damage
Todd B. Sherer,Ranjita Betarbet,Amy K. Stout,Serena Lund,Melisa J. Baptista,Alexander Panov,Mark R. Cookson,J. Timothy Greenamyre +7 more
TL;DR: These studies indicate that chronic low-grade complex I inhibition caused by rotenone exposure induces accumulation and aggregation of α-synuclein and ubiquitin, progressive oxidative damage, and caspase-dependent death, mechanisms that may be central to PD pathogenesis.