J
J. Tyson Tildon
Researcher at University of Maryland, Baltimore
Publications - 29
Citations - 1188
J. Tyson Tildon is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Glutamine & Ketoacidosis. The author has an hindex of 14, co-authored 29 publications receiving 1156 citations.
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Gastrointestinal abnormalities in children with autistic disorder.
TL;DR: The observed increase in pancreatico-biliary secretion after secretin infusion suggests an upregulation of secretin receptors in the pancreas and liver and may contribute to the behavioral problems of the non-verbal autistic patients.
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Transport ofl-lactate by cultured rat brain astrocytes
TL;DR: The results suggest that the availability of lactate as an energy source is regulated in part by a biphasic transport system in primary astrocytes.
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Energy Metabolism in Cortical Synaptic Terminals from Weanling and Mature Rat Brain: Evidence for Multiple Compartments of Tricarboxylic Acid Cycle Activity
TL;DR: The data demonstrate that synaptic terminals from both weanling and adult rat brain can utilize a variety of substrates for energy and suggest that there are multiple compartments of energy metabolism (or tricarboxylic acid cycle activity) in isolated synaptic terminals.
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Mitochondrial malic enzyme activity is much higher in mitochondria from cortical synaptic terminals compared with mitochondria from primary cultures of cortical neurons or cerebellar granule cells.
Mary C. McKenna,Joseph H. Stevenson,Xueli Huang,J. Tyson Tildon,Carol L. Zielke,Irene B. Hopkins +5 more
TL;DR: Data show that mME activity is highly enriched in cortical synaptic mitochondria compared to mitochondria from cultured cortical neurons, and a function in maintaining the intramitochondrial reduced glutathione in synaptic terminals is consistent with a role for mME in the pyruvate recycling pathway.
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Effect of fluorocitrate on cerebral oxidation of lactate and glucose in freely moving rats.
TL;DR: The current study utilizes the aconitase inhibitor fluorocitrate to differentially inhibit oxidative metabolism in glial cells in vivo to indicate that astrocytes oxidize about 50% of the interstitial lactate and about 35% ofthe glucose.