J
J. van der Greef
Researcher at Leiden University
Publications - 226
Citations - 6238
J. van der Greef is an academic researcher from Leiden University. The author has contributed to research in topics: Mass spectrometry & Capillary electrophoresis. The author has an hindex of 41, co-authored 226 publications receiving 6064 citations. Previous affiliations of J. van der Greef include University of Düsseldorf.
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Journal ArticleDOI
The art and practice of systems biology in medicine: mapping patterns of relationships.
J. van der Greef,Stephen A. Martin,Peter Juhasz,Aram Adourian,Thomas N. Plasterer,Elwin Verheij,Robert N. McBurney +6 more
TL;DR: The broad applicability of Systems Biology in pharmaceutical research and development is discussed with examples in disease biomarker research, in pharmacology using system response monitoring, and in cross-compartment system toxicology assessment.
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High-performance liquid chromatography with on-line coupled UV, mass spectrometric and biochemical detection for identification of acetylcholinesterase inhibitors from natural products
Kornkanok Ingkaninan,C.M. de Best,R. van der Heijden,A.J.P. Hofte,B. Karabatak,H. Irth,U.R. Tjaden,J. van der Greef,Robert Verpoorte +8 more
TL;DR: A high-performance liquid chromatography method with on-line coupled ultraviolet (UV), mass spectrometry (MS) and biochemical detection for acetylcholinesterase (AChE) inhibitory activity has been developed and AChE inhibitors can be rapidly identified.
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Isotachophoresis as an on-line concentration pretreatment technique in capillary electrophoresis.
TL;DR: It appeared that in non-treated capillaries the electromigration characteristics are hardly influenced when isotachophoretic pretreatment is applied, and detection limits could be lowered by at least two orders of magnitude.
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Neuropeptide expression and processing as revealed by direct matrix-assisted laser desorption ionization mass spectrometry of single neurons
Connie R. Jimenez,P. A. van Veelen,Ka Wan Li,Willem C. Wildering,Wijnand P. M. Geraerts,U.R. Tjaden,J. van der Greef +6 more
TL;DR: In one of the neuroendocrine systems studied, it is demonstrated for the first time, by comparing the peptide patterns of soma and of neurohemal axon terminals, that processing of the complex prohormone expressed in this system occurs entirely in the soma.
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Discovery of early-stage biomarkers for diabetic kidney disease using ms-based metabolomics (FinnDiane study)
F. van der Kloet,F. W.A. Tempels,N. Ismail,R.W. van der Heijden,Piotr T. Kasper,Miguel Rojas-Chertó,R. van Doorn,Gerwin Spijksma,Maud M. Koek,J. van der Greef,Ville-Petteri Mäkinen,Carol Forsblom,Harry Holthöfer,P. H. Groop,Theo H. Reijmers,Thomas Hankemeier +15 more
TL;DR: The potential of multivariate data analysis and metabolomics in the field of diabetic complications, and suggests several metabolic pathways relevant for further biological studies, is demonstrated.