J
J. Victor Small
Researcher at Austrian Academy of Sciences
Publications - 85
Citations - 10781
J. Victor Small is an academic researcher from Austrian Academy of Sciences. The author has contributed to research in topics: Lamellipodium & Arp2/3 complex. The author has an hindex of 53, co-authored 85 publications receiving 10157 citations. Previous affiliations of J. Victor Small include Institute of Molecular Biotechnology.
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The lamellipodium: where motility begins
TL;DR: A spatial inventory of the many molecular players in this dynamic domain of the actin cytoskeleton is given in order to highlight the open questions and the challenges ahead.
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Nascent Focal Adhesions Are Responsible for the Generation of Strong Propulsive Forces in Migrating Fibroblasts
TL;DR: Traction stress generated by fibroblasts expressing green fluorescent protein (GFP)-zyxin is mapped and it is revealed that the faint, small adhesions near the leading edge transmit strong propulsive tractions, whereas large, bright, mature focal adhesion exert weaker forces.
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Microtubule Targeting of Substrate Contacts Promotes Their Relaxation and Dissociation
TL;DR: The data are consistent with a mechanism whereby microtubules deliver localized doses of relaxing signals to contact sites to retard or reverse their development and propose that it is via this route that microtubule exert their well-established control on cell polarity.
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Targeting, Capture, and Stabilization of Microtubules at Early Focal Adhesions
TL;DR: It is speculated that microtubules are guided into substrate contact sites and through the motor-dependent delivery of signaling molecules serve to modulate their development, and this modulation provides the route whereby microtubule exert their influence on cell shape and polarity.
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Arp2/3 complex interactions and actin network turnover in lamellipodia
Frank P. L. Lai,Malgorzata Szczodrak,Jennifer Block,Jan Faix,Dennis Breitsprecher,Hans Georg Mannherz,Theresia E. B. Stradal,Graham Dunn,J. Victor Small,Klemens Rottner +9 more
TL;DR: It is shown that Arp2/3 complex is incorporated into the network exclusively at the lamellipodium tip, like actin, at sites coincident with WAVE complex accumulation, and uncoupled from the activities of both cortactin and cofilin.