In vivo Body Composition Studies.

Performance and exposure indices of rats exposed to low concentrations of lead.

The human environment contains more than 50 metal or metalloid elements. At least 15 are recognized as trace elements, with zinc, calcium, copper, magnesium, and iron having specific roles in skin morphogenesis and function. The present review focuses on the presumed role of metal ions in the skin, their competition for carrier proteins, and membrane receptors. Evidence presented shows that the balance of trace metal ions is critical for normal skin and repair mechanisms following injury. Xenobiotic ions can impair this balance, leading to pathological change. The skin acts as an organ of elimination of excess trace metals and xenobiotic ions from the body, but mechanisms of voidance vary for different metals.Metal ions are an important cause of allergies, and evidence is presented to show that the majority of metals or metal compounds can induce allergic changes. Except for chromium and nickel, which are among the most common human allergens, animal models have provided little information.At leas...

Physiological and toxicological changes in the skin resulting from the action and interaction of metal ions

J.W.T. Dickerson

Papers

Effect of age on the tissue distribution of lead in the rat

Concentrations of lead in the soft tissues of male rats during a long-term dietary exposure

Strain differences in lead intoxication in rats.