Jack B. Nitschke

TL;DR: Five processes that are essential for adaptive anticipatory responses to future threat uncertainty are identified and it is proposed that alterations in the neural instantiation of these processes result in maladaptive responses to uncertainty in pathological anxiety.

TL;DR: A model of the ways in which affect can become disordered in depression is constructed and proposals for the specific types of processing abnormalities that result from dysfunctions in different parts of this circuitry are offered.

TL;DR: These results, based on electrophysiological imaging, not only support hemodynamic findings implicating activation of the anterior cingulate as a predictor of response in depression, but they also suggest that differential activity in the rostral anterior cedulate is associated with gradations of response.

TL;DR: Hemispheric-specific analyses documented the importance of goal-directed approach tendencies beyond those captured by approach-related positive affect for eudaimonic but not for hedonic well-being, and greater left than right superior frontal activation was associated with higher levels of both forms ofWell-being.

TL;DR: Results show that anticipation of aversion recruits key brain regions that respond to aversion, thereby potentially enhancing adaptive responses to aversive events.