J
Jack D. Crouch
Researcher at National Institutes of Health
Publications - 3
Citations - 57
Jack D. Crouch is an academic researcher from National Institutes of Health. The author has contributed to research in topics: DNA & DNA repair. The author has an hindex of 2, co-authored 2 publications receiving 27 citations.
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Journal ArticleDOI
Epigenetic Regulation of Cellular Senescence
Jack D. Crouch,Maria Shvedova,Rex Jeya Rajkumar Samdavid Thanapaul,Vladimir A. Botchkarev,Daniel S. Roh +4 more
TL;DR: This review will highlight the changes in chromatin, DNA methylation, and histone alterations that establish and maintain cellular senescence, alongside the specific epigenetic regulation of the senescENCE-associated secretory phenotype (SASP).
Journal ArticleDOI
Biochemical Characterization of the Human Mitochondrial Replicative Twinkle Helicase: SUBSTRATE SPECIFICITY, DNA BRANCH MIGRATION, AND ABILITY TO OVERCOME BLOCKADES TO DNA UNWINDING.
Irfan Khan,Jack D. Crouch,Sanjay Kumar Bharti,Joshua A. Sommers,Sean M. Carney,Elena Yakubovskaya,Miguel Garcia-Diaz,Michael A. Trakselis,Robert M. Brosh +8 more
TL;DR: Novel single molecule FRET binding and unwinding assays show an interaction of the excluded strand with Twinkle as well as events corresponding to stepwise unwinding and annealing, suggesting other replisome proteins may be required for efficient removal.
Journal ArticleDOI
Mechanistic and biological considerations of oxidatively damaged DNA for helicase-dependent pathways of nucleic acid metabolism.
Jack D. Crouch,Robert M. Brosh +1 more
TL;DR: The roles of helicases in response to nuclear and mitochondrial oxidative stress are discussed and how this important class of enzymes help cells cope with oxidatively generated DNA damage through their functions in the replication stress response, DNA repair, and transcriptional regulation.