J
Jacob P. Brady
Researcher at University of Toronto
Publications - 14
Citations - 826
Jacob P. Brady is an academic researcher from University of Toronto. The author has contributed to research in topics: Endoplasmic reticulum & Membrane curvature. The author has an hindex of 8, co-authored 14 publications receiving 581 citations. Previous affiliations of Jacob P. Brady include University of Oxford & Imperial College London.
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Journal ArticleDOI
Structural and hydrodynamic properties of an intrinsically disordered region of a germ cell-specific protein on phase separation
Jacob P. Brady,Patrick Farber,Ashok Sekhar,Yi-Hsuan Lin,Rui Huang,Alaji Bah,Timothy J. Nott,Hue Sun Chan,Andrew Baldwin,Julie D. Forman-Kay,Lewis E. Kay +10 more
TL;DR: Observation of a network of interchain interactions, as established by NOE spectroscopy, shows the importance of Phe and Arg interactions in driving the phase separation of Ddx4, while the salt dependence of both low- and high-concentration regions of phase diagrams establishes an important role for electrostatic interactions.
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Specific DNA recognition mediated by a type IV pilin
Ana Cehovin,Peter Simpson,Melanie A. Mcdowell,Daniel R. Brown,Rossella Noschese,Mitchell A. Pallett,Jacob P. Brady,Geoffrey S. Baldwin,Susan M. Lea,Stephen Matthews,Vladimir Pelicic +10 more
TL;DR: It is shown that meningococcal type IV pili bind DNA through the minor pilin ComP via an electropositive stripe that is predicted to be exposed on the filaments surface and that ComP displays an exquisite binding preference for DNA uptake sequence.
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Charge pattern matching as a ‘fuzzy’ mode of molecular recognition for the functional phase separations of intrinsically disordered proteins
TL;DR: In this paper, the random-phase approximation (RPA) was extended to handle polyampholyte solutions containing two different IDP species, each containing a different set of volume fractions for the two IDP sequences.
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A conserved amphipathic helix is required for membrane tubule formation by Yop1p
TL;DR: The secondary structure and dynamics of the DP1 family protein produced from the YOP1 gene is characterized and a C-terminal conserved amphipathic helix (APH) that is necessary for membrane tubule formation is identified, indicating that APHs play a previously unrecognized role in RHD membrane curvature stabilization.
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A unified analytical theory of heteropolymers for sequence-specific phase behaviors of polyelectrolytes and polyampholytes
TL;DR: A theory that combines a random-phase-approximation treatment of polymer density fluctuations and an account of intrachain conformational heterogeneity based on renormalized Kuhn lengths to provide predictions of LLPS properties as a function of pH, salt, and charge patterning along the chain sequence is presented.