J
Jacobijn Gussekloo
Researcher at Leiden University Medical Center
Publications - 373
Citations - 18694
Jacobijn Gussekloo is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Population & Randomized controlled trial. The author has an hindex of 65, co-authored 344 publications receiving 16271 citations. Previous affiliations of Jacobijn Gussekloo include Leiden University & Loyola University Medical Center.
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Journal ArticleDOI
Subclinical hypothyroidism and the risk of coronary heart disease and mortality.
Nicolas Rodondi,Wendy P. J. den Elzen,Douglas C. Bauer,Anne R. Cappola,Salman Razvi,John P. Walsh,Bjørn Olav Åsvold,Giorgio Iervasi,Misa Imaizumi,Tinh-Hai Collet,Alexandra Bremner,Patrick Maisonneuve,José Augusto Sgarbi,Kay-Tee Khaw,Mark Vanderpump,Anne B. Newman,Jacques Cornuz,Jayne A. Franklyn,Rudi G. J. Westendorp,Eric Vittinghoff,Jacobijn Gussekloo +20 more
TL;DR: Subclinical hypothyroidism is associated with an increased risk of CHD events and CHD mortality in those with higher TSH levels, particularly inThose with a TSH concentration of 10 mIU/L or greater.
Journal ArticleDOI
Thyroid Status, Disability and Cognitive Function, and Survival in Old Age
Jacobijn Gussekloo,Eric van Exel,Anton J. M. de Craen,Arend E Meinders,Marijke Frölich,Rudi G. J. Westendorp +5 more
TL;DR: In the general population of the oldest old, elderly individuals with abnormally high levels of thyrotropin do not experience adverse effects and may have a prolonged life span, however, evidence for not treating elderly individuals can only come from a well-designed, randomized placebo-controlled clinical trial.
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Handgrip strength as a predictor of functional, psychological and social health. A prospective population-based study among the oldest old
Diana G. Taekema,Jacobijn Gussekloo,Andrea B. Maier,Rudi G. J. Westendorp,Anton J. M. de Craen +4 more
TL;DR: Poor handgrip strength predicts accelerated dependency in ADL and cognitive decline in oldest old, and could be a useful instrument in geriatric practice to identify those oldest old patients at risk for this accelerated decline.
Journal ArticleDOI
Successful aging in the oldest old: Who can be characterized as successfully aged?
M. von Faber,A Bootsma-van der Wiel,E. van Exel,Jacobijn Gussekloo,A. M. Lagaay,E. van Dongen,D.L. Knook,S. van der Geest,Rudi G. J. Westendorp +8 more
TL;DR: Analysis of data from the first cross-sectional part of the longitudinal Leiden 85-plus Study showed that most elderly persons viewed success as a process of adaptation rather than a state of being, and only a happy few meet the criteria.
Journal ArticleDOI
Meta-analysis: Subclinical Thyroid Dysfunction and the Risk for Coronary Heart Disease and Mortality
Nicolas Ochs,Reto Auer,Douglas C. Bauer,David Nanchen,Jacobijn Gussekloo,Jacques Cornuz,Nicolas Rodondi +6 more
TL;DR: This systematic review of 12 prospective cohort studies found that both subclinical hypothyroidism and hyperthyroidism were possibly associated with a small increased risk for coronary heart disease and mortality.