Jacqueline A. Jones

TL;DR: It was concluded that topography affects macrophage behavior in the foreign body response on all polymer surfaces examined, and does affect cell morphology and cytokine secretion in vitro, and cell adhesion in vivo particularly on larger size topography compared to planar controls.

TL;DR: Evidence that material surface chemistry can differentially affect monocyte/macrophage/FB GC adhesion and cytokine/chemokine profiles derived from activated macrophages/FBGCs adherent to biomaterial surfaces is presented.

TL;DR: It is suggested that adsorbed vitronectin is critical in the collective events that support and promote FBGC formation on biomedical polymers, and that the propensity for vitronECTin adsorption may underlie the material surface chemistry dependency of FB GC formation.

TL;DR: Analysis of the MMP/TIMP quantities produced per cell revealed that the hydrophilic/neutral surfaces, which inhibited macrophage adhesion, activated the adherent macrophages/FBGCs to produce a greater quantity of MMP-9, TIMP, and TIMP-2 per cell.

TL;DR: Surface modification of biomaterials offer an opportunity to control cellular activation and cytokine profiles in the phenotypic switch, and may provide a means by which macrophages can be induced to regulate particular secretory proteins that direct inflammation, the foreign body reaction, wound healing, and ultimately biocompatibility.