J
Jacqueline T. Hecht
Researcher at University of Texas Health Science Center at Houston
Publications - 19
Citations - 866
Jacqueline T. Hecht is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Cartilage oligomeric matrix protein & Pseudoachondroplasia. The author has an hindex of 8, co-authored 19 publications receiving 767 citations. Previous affiliations of Jacqueline T. Hecht include University of Colorado Denver & University of Texas at Austin.
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Journal ArticleDOI
Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia.
Jacqueline T. Hecht,Laura D. Nelson,Eric Crowder,Yang Wang,Frederick F.B. Elder,Wilbur Harrison,Clair A. Francomano,Christa Prange,Gregory G. Lennon,Michelle Deere,Jack Lawler +10 more
TL;DR: The results demonstrate that mutations in the COMP gene cause pseudochondroplasia, a well characterized dwarfing condition mapping to chromosome 19p12–13.
Journal ArticleDOI
Pseudoachondroplasia and multiple epiphyseal dysplasia: New etiologic developments.
Sheila Unger,Jacqueline T. Hecht +1 more
TL;DR: The clinical features of PSACH and MED, the known mutations, and the pathogenetic effect of COMP mutations on the cartilage extracellular matrix are reviewed, making MED one of the most genetically heterogeneous disorders.
Journal ArticleDOI
COMP mutations, chondrocyte function and cartilage matrix.
TL;DR: The combined absence of COMP, type IX collagen and MATN3 causes dramatic changes in the matrix and suggests that these proteins play important roles in matrix assembly.
Journal ArticleDOI
Diminished levels of the putative tumor suppressor proteins EXT1 and EXT2 in exostosis chondrocytes.
Mark A. Bernard,Mark A. Bernard,Catherine E. Hall,Catherine E. Hall,Catherine E. Hall,Deborah Hogue,Deborah Hogue,Deborah Hogue,William G. Cole,William G. Cole,Allison Scott,Allison Scott,Allison Scott,Mark B. Snuggs,Gregory A. Clines,Gregory A. Clines,Gregory A. Clines,H.-J. Lüdecke,Michael Lovett,Michael Lovett,Michael Lovett,W. Van Barry Winkle,Jacqueline T. Hecht,Jacqueline T. Hecht +23 more
TL;DR: It is suggested that multiple mutational steps are involved in exostosis development and that EXT genes play a role in cell signaling related to chondrocyte cytoskeleton regulation.
Journal ArticleDOI
Role of TSP-5/COMP in pseudoachondroplasia.
TL;DR: Gene therapy will need to target the reduction of COMP in order to restore normal chondrocyte function and longevity as well as other misfolded proteins that are targeted for degradation.