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Mark A. Bernard
Researcher at Beth Israel Deaconess Medical Center
Publications - 19
Citations - 453
Mark A. Bernard is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Hydrogen bond & Collagen receptor. The author has an hindex of 11, co-authored 19 publications receiving 423 citations. Previous affiliations of Mark A. Bernard include University of Texas Health Science Center at Houston & Oregon State University.
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Journal ArticleDOI
Novel HIV-1 MiRNAs Stimulate TNFα Release in Human Macrophages via TLR8 Signaling Pathway
TL;DR: Data support a potential role for HIV-derived vmiRNAs released from infected macrophages as contributing to chronic immune activation in HIV-infected persons, and may represent a novel therapeutic target to limit AIDS pathogenesis.
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Diminished levels of the putative tumor suppressor proteins EXT1 and EXT2 in exostosis chondrocytes.
Mark A. Bernard,Mark A. Bernard,Catherine E. Hall,Catherine E. Hall,Catherine E. Hall,Deborah Hogue,Deborah Hogue,Deborah Hogue,William G. Cole,William G. Cole,Allison Scott,Allison Scott,Allison Scott,Mark B. Snuggs,Gregory A. Clines,Gregory A. Clines,Gregory A. Clines,H.-J. Lüdecke,Michael Lovett,Michael Lovett,Michael Lovett,W. Van Barry Winkle,Jacqueline T. Hecht,Jacqueline T. Hecht +23 more
TL;DR: It is suggested that multiple mutational steps are involved in exostosis development and that EXT genes play a role in cell signaling related to chondrocyte cytoskeleton regulation.
Journal ArticleDOI
Metabolic functions of microbial nucleoside diphosphate kinases.
Mark A. Bernard,Nancy B. Ray,Nancy B. Ray,Michael C. Olcott,Stephen P. Hendricks,Christopher K. Mathews +5 more
TL;DR: This article summarizes research from the laboratory on two aspects of the biochemistry of nucleoside diphosphate kinase from Escherichia coli—first, its interactions with several T4bacteriophage-coded enzymes, as part of a multienzyme complex for deoxyribonucleosidetriphosphate biosynthesis and phenotypes of an E. coli mutant strain carrying a targeted deletion of ndk.
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T4 phage gene 32 protein as a candidate organizing factor for the deoxyribonucleoside triphosphate synthetase complex.
Linda J. Wheeler,Nancy B. Ray,Christian Ungermann,Stephen P. Hendricks,Mark A. Bernard,Eric S. Hanson,Christopher K. Mathews +6 more
TL;DR: The data suggest a model in which dNTP synthetase complexes, probably more than one per growing DNA chain, are drawn to replication forks via their affinity for gp32 and hence are localized so as to produce dN TPs at their sites of utilization, immediately ahead of growing DNA 3′ termini.
Journal ArticleDOI
Cytoskeletal abnormalities in chondrocytes with EXT1 and EXT2 mutations.
Mark A. Bernard,Deborah Hogue,William G. Cole,Tiffany Sanford,Mark B. Snuggs,Dina Montufar-Solis,P. Jackie Duke,Daniel D. Carson,Allison Scott,W. Barry Van Winkle,Jacqueline T. Hecht +10 more
TL;DR: Exostosis chondrocytes from three patients with HME and from one individual with a non‐HME, isolated exostosis are characterized, suggesting that mutations in the EXT genes cause abnormal processing of cytoskeleton proteins in chondrosarcomas.