J
Jacques P. Guyette
Researcher at Harvard University
Publications - 24
Citations - 1935
Jacques P. Guyette is an academic researcher from Harvard University. The author has contributed to research in topics: Decellularization & Mesenchymal stem cell. The author has an hindex of 12, co-authored 24 publications receiving 1632 citations. Previous affiliations of Jacques P. Guyette include Worcester Polytechnic Institute.
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Journal ArticleDOI
Regeneration and experimental orthotopic transplantation of a bioengineered kidney
Jeremy Song,Jacques P. Guyette,Sarah E. Gilpin,Gabriel Gonzalez,Joseph P. Vacanti,Harald C. Ott +5 more
TL;DR: To regenerate functional tissue, rat kidney scaffolds are seeded with epithelial and endothelial cells and perfused these cell-seeded constructs in a whole-organ bioreactor, resulting in grafts that produced rudimentary urine in vitro when perfused through their intrinsic vascular bed.
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Bioengineering Human Myocardium on Native Extracellular Matrix
Jacques P. Guyette,Jonathan M. Charest,Robert W. Mills,Bernhard J. Jank,Philipp T. Moser,Sarah E. Gilpin,Joshua R. Gershlak,Tatsuya Okamoto,Gabriel Gonzalez,David J. Milan,Glenn R. Gaudette,Harald C. Ott +11 more
TL;DR: Native cardiac extracellular matrix scaffolds maintain matrix components and structure to support the seeding and engraftment of human induced pluripotent stem cell-derived cardiomyocytes and enable the bioengineering of functional human myocardial-like tissue of multiple complexities.
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Perfusion decellularization of human and porcine lungs: bringing the matrix to clinical scale.
Sarah E. Gilpin,Jacques P. Guyette,Gabriel Gonzalez,Xi Ren,John M. Asara,Douglas J. Mathisen,Joseph P. Vacanti,Harald C. Ott +7 more
TL;DR: SDS-based perfusion decellularization can be applied to whole porcine and human lungs to generate biocompatible organ scaffolds with preserved ECM composition and architecture.
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Perfusion decellularization of whole organs
TL;DR: Combining the unique structural and biochemical properties of native acellular scaffolds with subsequent recellularization techniques offers a novel platform for organ engineering and regeneration, for experimentation ex vivo and potential clinical application in vivo.
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Enhanced lung epithelial specification of human induced pluripotent stem cells on decellularized lung matrix.
Sarah E. Gilpin,Xi Ren,Tatsuya Okamoto,Jacques P. Guyette,Hongmei Mou,Jayaraj Rajagopal,Douglas J. Mathisen,Joseph P. Vacanti,Harald C. Ott +8 more
TL;DR: Decellularized lung matrix supports the culture and lineage commitment of human iPSC-derived lung progenitor cells and may enable further in vivo graft maturation and enhance early lung fate.