J
Jagadeesan Nair
Researcher at German Cancer Research Center
Publications - 51
Citations - 4749
Jagadeesan Nair is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Lipid peroxidation & DNA damage. The author has an hindex of 32, co-authored 51 publications receiving 4530 citations.
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Dietary polyunsaturated fatty acids and cancers of the breast and colorectum: emerging evidence for their role as risk modifiers.
TL;DR: Current evidence from experimental and human studies is summarized that implicates a high intake of omega-6 PUFAs in cancer of the breast, colon and, possibly, prostate and which indicates that omega-3PUFAs and monounsaturated fatty acids such as oleic acid (omega-9) are protective.
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Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair
Helmut Bartsch,Jagadeesan Nair +1 more
TL;DR: Persistent oxidative/nitrosative stress and excess LPO are induced by inflammatory processes in a self-perpetuating process and cause progressive accumulation of DNA damage in target organs, providing promising molecular signatures for risk prediction and potential targets and biomarkers for preventive measures.
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Alert for an epidemic of oral cancer due to use of the betel quid substitutes gutkha and pan masala: a review of agents and causative mechanisms
TL;DR: Evidence that strongly supports causative mechanisms for genotoxicity and carcinogenicity of these substitute products, including gutkha and pan masala, are strongly implicated in the recent increase in the incidence of oral submucous fibrosis is reviewed.
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Lipid peroxidation-induced DNA damage in cancer-prone inflammatory diseases: A review of published adduct types and levels in humans
TL;DR: The accuracy of the available methods and their validation is critically discussed and studies in which measurement of exocyclic adducts suggested new mechanisms of cancer causation are summarized, providing potential biomarkers for cancer risk assessment in humans with cancer-prone diseases.
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Oxidative stress and lipid peroxidation-derived DNA-lesions in inflammation driven carcinogenesis
Helmut Bartsch,Jagadeesan Nair +1 more
TL;DR: Epsilon-DNA adducts may serve as potential markers for assessing progression of inflammatory cancer-prone diseases and the efficacy of human chemopreventive interventions could be verified by using the non-invasive urine assay.