https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep.21907

Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis

Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis.

https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep.1840220145

The treatment of portal hypertension: A meta-analytic review

https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep.1840050313

Portal pressure, presence of gastroesophageal varices and variceal bleeding.

https://www.gastrojournal.org/article/0016-5085(90)91168-6/pdf

Hemodynamic events in a prospective randomized trial of propranolol versus placebo in the prevention of a first variceal hemorrhage

https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep.1840020602

Nitroglycerin improves the hemodynamic response to vasopressin in portal hypertension

https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep.1840040312

Measurement of azygos venous blood flow by a continuous thermal dilution technique: an index of blood flow through gastroesophageal collaterals in cirrhosis.

Background & Aims: Patients with cirrhosis develop abnormal hematologic indices (HI) from multiple factors, including hypersplenism. We aimed to analyze the sequence of events and determine whether abnormal HI has prognostic significance. Methods: We analyzed a database of 213 subjects with compensated cirrhosis without esophageal varices. Subjects were followed for approximately 9 years until the development of varices or variceal bleeding or completion of the study; 84 subjects developed varices. Abnormal HI was defined as anemia at baseline (hemoglobin, <13.5 g/dL for men and 11.5 g/dL for women), leukopenia (white blood cell counts, <4000/mm 3 ), or thrombocytopenia (platelet counts, <150,000/mm3). The primary end points were death or transplant surgery. Results: Most subjects had thrombocytopenia at baseline. Kaplan‐ Meier analysis showed that leukopenia occurred by 30 months (95% confidence interval, 18.5‐53.6), and anemia occurred by 39.6 months (95% confidence interval, 24.1‐ 49.9). Baseline thrombocytopenia (P .0191) and leukopenia (P .0383) were predictors of death or transplant, after adjusting for baseline hepatic venous pressure gradient (HVPG), and Child‐Pugh scores. After a median of 5 years, a significant difference in death or transplant, mortality, and clinical decompensation was observed in patients who had leukopenia combined with thrombocytopenia at baseline compared with patients with normal HI (P < .0001). HVPG correlated with hemoglobin and white blood cell count (hemoglobin, r 0.35, P < .0001; white blood cell count, r 0.31, P < .0001). Conclusions: Thrombocytopenia is the most common and first abnormal HI to occur in patients with cirrhosis, followed by leukopenia and anemia. A combination of leukopenia and thrombocytopenia at baseline predicted increased morbidity and mortality.

https://www.cghjournal.org/article/S1542-3565(09)00200-6/pdf

ORIGINAL ARTICLES—LIVER, PANCREAS, AND BILIARY TRACT Incidence, Prevalence, and Clinical Significance of Abnormal Hematologic Indices in Compensated Cirrhosis

Textbook of Clinical Gastroenterology and Hepatology: Hawkey/Textbook of Clinical Gastroenterology and Hepatology

(HR, 0.37; 95% CI, 0.22‐0.62). Diagnostic capacity of HVPG was greater than for MELD or Child‐Pugh score. Conclusions: HVPG, MELD, and albumin independently predict clinical decompensation in patients with compensated cirrhosis. Patients with an HVPG <10 mm Hg have a 90% probability of not developing clinical decompensation in a median follow-up of 4 years.

https://www.gastrojournal.org/article/S0016-5085(07)01006-2/pdf

Jaime Bosch

Papers

Nitroglycerin improves the hemodynamic response to vasopressin in portal hypertension

Measurement of azygos venous blood flow by a continuous thermal dilution technique: an index of blood flow through gastroesophageal collaterals in cirrhosis.

ORIGINAL ARTICLES—LIVER, PANCREAS, AND BILIARY TRACT Incidence, Prevalence, and Clinical Significance of Abnormal Hematologic Indices in Compensated Cirrhosis

Textbook of Clinical Gastroenterology and Hepatology: Hawkey/Textbook of Clinical Gastroenterology and Hepatology

Clinical-liver, pancreas, and biliary tract