So far in this course we have dealt entirely with the evolution of characters that are controlled by simple Mendelian inheritance at a single locus. There are notes on the course website about gametic disequilibrium and how allele frequencies change at two loci simultaneously, but we didn’t discuss them. In every example we’ve considered we’ve imagined that we could understand something about evolution by examining the evolution of a single gene. That’s the domain of classical population genetics. For the next few weeks we’re going to be exploring a field that’s actually older than classical population genetics, although the approach we’ll be taking to it involves the use of population genetic machinery. If you know a little about the history of evolutionary biology, you may know that after the rediscovery of Mendel’s work in 1900 there was a heated debate between the “biometricians” (e.g., Galton and Pearson) and the “Mendelians” (e.g., de Vries, Correns, Bateson, and Morgan). Biometricians asserted that the really important variation in evolution didn’t follow Mendelian rules. Height, weight, skin color, and similar traits seemed to

Human biochemical genetics

We will review some of the major results in random graphs and some of the more challenging open problems. We will cover algorithmic and structural questions. We will touch on newer models, including those related to the WWW.

Random graphs

The present historical moment may seem a particularly inopportune time to review Bowling Alone, Robert Putnam's latest exploration of civic decline in America. After all, the outpouring of volunteerism, solidarity, patriotism, and self-sacrifice displayed by Americans in the wake of the September 11 terrorist attacks appears to fly in the face of Putnam's central argument: that \"social capital\" -defined as \"social networks and the norms of reciprocity and trustworthiness that arise from them\" (p. 19)'has declined to dangerously low levels in America over the last three decades. However, Putnam is not fazed in the least by the recent effusion of solidarity. Quite the contrary, he sees in it the potential to \"reverse what has been a 30to 40-year steady decline in most measures of connectedness or community.\"' As an example of how the current \"war on terrorism\" could generate a durable civic renewal, Putnam points to the burst in civic practices that occurred during and after World War II, which he says \"permanently marked\" the generation that lived through it and had a \"terrific effect on American public life over the last half-century.\" 3 If Americans can follow this example and channel their current civic

Bowling alone: The collapse and revival of American community

The COVID-19 pandemic represents a massive global health crisis. Because the crisis requires large-scale behaviour change and places significant psychological burdens on individuals, insights from the social and behavioural sciences can be used to help align human behaviour with the recommendations of epidemiologists and public health experts. Here we discuss evidence from a selection of research topics relevant to pandemics, including work on navigating threats, social and cultural influences on behaviour, science communication, moral decision-making, leadership, and stress and coping. In each section, we note the nature and quality of prior research, including uncertainty and unsettled issues. We identify several insights for effective response to the COVID-19 pandemic and highlight important gaps researchers should move quickly to fill in the coming weeks and months.

/pdf/using-social-and-behavioural-science-to-support-covid-19-25vr5kyvxt.pdf

Using social and behavioural science to support COVID-19 pandemic response.

Originally published in Contemporary Psychology: APA Review of Books, 1994, Vol 39(2), 225. Reviews the book, The Nature and Origins of Mass Opinion by John Zaller (1992). The author's commendable effort to specify a model of mass opinion formation offers readers an introduction to the prevailing vi

The Nature and Origins of Mass Opinion.

Online social networks are everywhere. They must be influencing the way society is developing, but hard evidence is scarce. For instance, the relative effectiveness of online friendships and face-to-face friendships as drivers of social change is not known. In what may be the largest experiment ever conducted with human subjects, James Fowler and colleagues randomly assigned messages to 61 million Facebook users on Election Day in the United States in 2010, and tracked their behaviour both online and offline, using publicly available records. The results show that the messages influenced the political communication, information-seeking and voting behaviour of millions of people. Social messages had more impact than informational messages and 'weak ties' were much less likely than 'strong ties' to spread behaviour via the social network. Thus online mobilization works primarily through strong-tie networks that may exist offline but have an online representation.

https://jasonjones.ninja/papers/massive_turnout.pdf

A 61-million-person experiment in social influence and political mobilization

Some social connections are stronger than others. People have not only friends, but also best friends. Social scientists have long recognized this characteristic of social connections and researchers frequently use the term tie strength to refer to this concept. We used online interaction data (specifically, Facebook interactions) to successfully identify real-world strong ties. Ground truth was established by asking users themselves to name their closest friends in real life. We found the frequency of online interaction was diagnostic of strong ties, and interaction frequency was much more useful diagnostically than were attributes of the user or the user's friends. More private communications (messages) were not necessarily more informative than public communications (comments, wall posts, and other interactions).

/pdf/inferring-tie-strength-from-online-directed-behavior-1f9nr76jpr.pdf

Inferring tie strength from online directed behavior.

It is well known that humans tend to associate with other humans who have similar characteristics, but it is unclear whether this tendency has consequences for the distribution of genotypes in a population. Although geneticists have shown that populations tend to stratify genetically, this process results from geographic sorting or assortative mating, and it is unknown whether genotypes may be correlated as a consequence of nonreproductive associations or other processes. Here, we study six available genotypes from the National Longitudinal Study of Adolescent Health to test for genetic similarity between friends. Maps of the friendship networks show clustering of genotypes and, after we apply strict controls for population stratification, the results show that one genotype is positively correlated (homophily) and one genotype is negatively correlated (heterophily). A replication study in an independent sample from the Framingham Heart Study verifies that DRD2 exhibits significant homophily and that CYP2A6 exhibits significant heterophily. These unique results show that homophily and heterophily obtain on a genetic (indeed, an allelic) level, which has implications for the study of population genetics and social behavior. In particular, the results suggest that association tests should include friends’ genes and that theories of evolution should take into account the fact that humans might, in some sense, be metagenomic with respect to the humans around them.

http://fowler.ucsd.edu/correlated_genotypes_in_friendship_networks.pdf

Correlated genotypes in friendship networks

One of the strongest regularities in the empirical political science literature is the well-known correlation in parent and child partisan behavior. Until recently this phenomenon was thought to result solely from parental socialization, but new evidence on genetic sources of behavior suggests it might also be due to heritability. In this article we hypothesize that genes contribute to variation in a general tendency toward strength of partisanship. Using data collected at the Twins Days Festival, we compare the similarity of partisan strength in identical twins who share all of their genes to the similarity of partisan strength in non-identical twins who share only half of their genes. The results show that heritability accounts for almost half of the variance in strength of partisan attachment, and they suggest that we should pay closer attention to the role of biology in the expression of important political behaviors.

The Heritability of Partisan Attachment

Scholars in many fields have long noted the importance of social context in the development of political ideology. Recent work suggests that political ideology also has a heritable component, but no specific gene variant associated with political ideology has so far been identified. In this article we hypothesize that individuals with a genetic predisposition towards seeking out new experiences will tend to be more liberal, but only if they are embedded in a social context that provides them with multiple points of view. Using data from the National Longitudinal Study of Adolescent Health, we test this hypothesis by investigating an association between self-reported political ideology and the 7R variant of the dopamine receptor D4 gene (DRD4), which has previously been associated with novelty-seeking. We find that the number of friendships a person has in adolescence is significantly associated with liberal political ideology among those with DRD4-7R. Among those without the gene variant there is no association. This is the first study ever to elaborate a specific gene-environment interaction that contributes to ideological self-identification, and it highlights the importance of incorporating both nature and nurture into the study of politics.

/pdf/friendships-moderate-an-association-between-a-dopamine-gene-4aetma1vu4.pdf

Jaime E. Settle

Papers

A 61-million-person experiment in social influence and political mobilization

Inferring tie strength from online directed behavior.

Correlated genotypes in friendship networks

The Heritability of Partisan Attachment

Friendships Moderate an Association Between a Dopamine Gene Variant and Political Ideology