J
Jamal Khalife
Researcher at Pasteur Institute
Publications - 111
Citations - 3488
Jamal Khalife is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Plasmodium falciparum & Schistosoma mansoni. The author has an hindex of 32, co-authored 105 publications receiving 3223 citations. Previous affiliations of Jamal Khalife include French Institute of Health and Medical Research & University of Lille Nord de France.
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Journal ArticleDOI
Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities
Christophe Biot,Wassim Daher,Natascha Chavain,Thierry Fandeur,Jamal Khalife,Daniel Dive,Erik De Clercq +6 more
TL;DR: Three ferroquine derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared and exert antiviral effects with some selectivity toward SARS-CoV infection.
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The antimalarial ferroquine: role of the metal and intramolecular hydrogen bond in activity and resistance.
Faustine Dubar,Timothy J. Egan,Bruno Pradines,David J. Kuter,Kanyile K. Ncokazi,Delphine Forge,Jean-François Paul,Christine Pierrot,Hadidjatou Kalamou,Jamal Khalife,Eric Buisine,Christophe Rogier,Hervé Vezin,Isabelle Forfar,Christian Slomianny,Xavier Trivelli,Sergey Kapishnikov,Leslie Leiserowitz,Daniel Dive,Christophe Biot +19 more
TL;DR: Combination of physicochemical and molecular modeling methods showed that FQ and RQ favor intramolecular hydrogen bonding between the 4-aminoquinoline NH group and the terminal amino group in the absence of water, suggesting that this structure may enhance its passage through the membrane.
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The antimalarial ferroquine: from bench to clinic
Christophe Biot,François Nosten,Laurent Fraisse,Daniel Ter-Minassian,Jamal Khalife,Daniel Dive +5 more
TL;DR: This article focuses on the discovery of FQ, its antimalarial activity, the hypothesis of its mode of action, the current absence of resistance in vitro and recent clinical trials.
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Immunity in human schistosomiasis mansoni: prevention by blocking antibodies of the expression of immunity in young children.
Anthony E. Butterworth,R. Bensted-Smith,André Capron,Monique Capron,P.R. Dalton,David W. Dunne,J. M. Grzych,H. C. Kariuki,Jamal Khalife,D.K. Koech,Mercy M Mugambi,John H. Ouma,T.K.Arap Siongok,Robert F. Sturrock +13 more
TL;DR: In this article, a statistical analysis of the relationship between various immune responses and subsequent reinfection was presented, which is consistent with the hypothesis that early infections elicit the development, in response to egg antigens, of antibodies that block immune mechanisms directed against schistosomula.
Journal ArticleDOI
Ferroquine, an Ingenious Antimalarial Drug –Thoughts on the Mechanism of Action
TL;DR: After fifteen years of effort, it is now possible to propose a multifactorial mechanism of action of FQ by its capacity to target lipids, to inhibit the formation of hemozoin and to generate reactive oxygen species.