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Xavier Trivelli
Researcher at Lille University of Science and Technology
Publications - 72
Citations - 2781
Xavier Trivelli is an academic researcher from Lille University of Science and Technology. The author has contributed to research in topics: Catalysis & Chemistry. The author has an hindex of 26, co-authored 64 publications receiving 2364 citations. Previous affiliations of Xavier Trivelli include University of Montpellier & École supérieure de chimie physique électronique de Lyon.
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Journal ArticleDOI
Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria.
Anil K. Ojha,Anthony D. Baughn,Dhinakaran Sambandan,Tsungda Hsu,Xavier Trivelli,Yann Guérardel,Anuradha Alahari,Laurent Kremer,William R. Jacobs,Graham F. Hatfull +9 more
TL;DR: It is shown that M. tuberculosis forms biofilms with specific environmental and genetic requirements distinct from those for planktonic growth, which contain an extracellular matrix rich in free mycolic acids, and harbour an important drug‐tolerant population that persist despite exposure to high levels of antibiotics.
Journal ArticleDOI
Manganese Pincer Complexes for the Base-Free, Acceptorless Dehydrogenative Coupling of Alcohols to Esters: Development, Scope, and Understanding
Duc Hanh Nguyen,Xavier Trivelli,Frédéric Capet,Jean-François Paul,Franck Dumeignil,Régis M. Gauvin +5 more
TL;DR: In this article, a pincer-supported earth-abundant manganese(I) dicarbonyl complexes behave as effective catalysts for the acceptorless dehydrogenative coupling of a wide range of alcohols to esters under base-free conditions.
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The antimalarial ferroquine: role of the metal and intramolecular hydrogen bond in activity and resistance.
Faustine Dubar,Timothy J. Egan,Bruno Pradines,David J. Kuter,Kanyile K. Ncokazi,Delphine Forge,Jean-François Paul,Christine Pierrot,Hadidjatou Kalamou,Jamal Khalife,Eric Buisine,Christophe Rogier,Hervé Vezin,Isabelle Forfar,Christian Slomianny,Xavier Trivelli,Sergey Kapishnikov,Leslie Leiserowitz,Daniel Dive,Christophe Biot +19 more
TL;DR: Combination of physicochemical and molecular modeling methods showed that FQ and RQ favor intramolecular hydrogen bonding between the 4-aminoquinoline NH group and the terminal amino group in the absence of water, suggesting that this structure may enhance its passage through the membrane.
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Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria
Anuradha Alahari,Xavier Trivelli,Yann Guérardel,Lynn G. Dover,Gurdyal S. Besra,James C. Sacchettini,Robert C. Reynolds,Geoffrey D. Coxon,Laurent Kremer,Laurent Kremer +9 more
TL;DR: In this article, the authors employed various complementary approaches to show that the antitubercular drug, thiacetazone (TAC), and its chemical analogues, inhibit mycolic acid cyclopropanation.
Journal ArticleDOI
Enzymatic hydrolysis of trehalose dimycolate releases free mycolic acids during mycobacterial growth in biofilms.
TL;DR: This study provides the first evidence for an enzymatic release of free mycolic acids from cell envelope mycolates during mycobacterial growth, and suggests the presence of a TDM-specific esterase in M. tuberculosis.