James A. Wallace

TL;DR: Medullary 5-HT neurons complete much of their migration before they can be detected immunocytochemically, indicating that the time of onset of transmitter synthesis and storage may differ during differentiation of cells sharing a common neurotransmitter phenotype.

TL;DR: The results show that a differential expression of MMPs by astrocytes, microglia, and endothelial cells at the blood vessels is involved in the proteolytic disruption of the BBB.

TL;DR: The normal ontogeny of the serotonergic (5-HT) system in the rat brain as studied using long survival 3H-thymidine autoradiography and the Falck-Hillarp histofluorescence method and immunocytochemistry is described, which enhance the possibility that 5-HT neurons could exert an epigenetic influence on the development of less differentiated cells with which they come into contact.

TL;DR: Studies suggest that 5-HT (and possibly the other monoamine transmitters) may actually "mold" the construction of their own circuitry during neurogenesis, and the ability of drugs and stress to interact with this process during that period of gestation when the monoamines are required as humoral signals suggests that maternal influences can interfere with ontogeny of this circuitry during pre- and possibly postnatal development.

TL;DR: Based on the immunocytochemical staining patterns observed, and the fact that both 5-MT and tryptamine are found in very low quantities in the normal rat brain, it appears that 5-HT is the predominant indoleamine stained by both of these antisera in the untreated rat brain.