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Edward Y. Estrada
Researcher at University of New Mexico
Publications - 13
Citations - 2119
Edward Y. Estrada is an academic researcher from University of New Mexico. The author has contributed to research in topics: Blood–brain barrier & Vascular permeability. The author has an hindex of 11, co-authored 13 publications receiving 2054 citations. Previous affiliations of Edward Y. Estrada include Veterans Health Administration.
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Journal ArticleDOI
Matrix Metalloproteinases and TIMPs Are Associated With Blood-Brain Barrier Opening After Reperfusion in Rat Brain
TL;DR: Brain sucrose uptake increased after 3 and 48 hours of reperfusion, with maximal opening at 48 hours and return to normal by 14 days, suggesting different mechanisms of injury for the biphasic BBB injury.
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Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures.
Gary A. Rosenberg,Lee Anna Cunningham,James A. Wallace,Susan Alexander,Edward Y. Estrada,Mark Grossetete,Abbas Razhagi,K.M. Miller,Andrew J. H. Gearing +8 more
TL;DR: The results show that a differential expression of MMPs by astrocytes, microglia, and endothelial cells at the blood vessels is involved in the proteolytic disruption of the BBB.
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TIMP-2 reduces proteolytic opening of blood-brain barrier by type IV collagenase.
Gary A. Rosenberg,Gary A. Rosenberg,Mario Kornfeld,Edward Y. Estrada,Robert O. Kelley,Lance A. Liotta,William G. Stetler-Stevenson +6 more
TL;DR: To investigate this hypothesis, adult rats underwent intracerebral injection of type IV collagenase purified from human melanoma cells, and metalloproteinase inhibitors reduce extracellular matrix proteolysis and protect the blood-brain barrier.
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Tumor necrosis factor-α-induced gelatinase B causes delayed opening of the blood-brain barrier: an expanded therapeutic window
Gary A. Rosenberg,Gary A. Rosenberg,Edward Y. Estrada,John E. Dencoff,William G. Stetler-Stevenson +4 more
TL;DR: G gelatinase B is the intermediate substance linking TNF to modulation of capillary permeability, and agents that interfere with transcription of proteolytic enzymes or block their action may reduce delayed capillary injury, extending the therapeutic window.
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Bacterial collagenase disrupts extracellular matrix and opens blood-brain barrier in rat.
TL;DR: It is concluded that bacterial collagenase disrupts ECM and opens BBB, which causes hemorrhagic necrosis of brain and opens blood-brain barrier.