J
James A. Wright
Researcher at Florida State University
Publications - 21
Citations - 294
James A. Wright is an academic researcher from Florida State University. The author has contributed to research in topics: Enone & Aqueous two-phase system. The author has an hindex of 9, co-authored 21 publications receiving 268 citations. Previous affiliations of James A. Wright include Hoffmann-La Roche.
Papers
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Journal ArticleDOI
Triaryl methane derivatives as antiproliferative agents
Raed A. Al-Qawasmeh,Yoon Cheol Lee,Ming Yu Cao,Xiaoping Gu,Aikaterini Vassilakos,James A. Wright,Aiping Young +6 more
TL;DR: In this paper, a flow cytometric analysis demonstrated that the decrease in tumor cell growth by CLT 1 was associated with inhibition of cell cycle progression at the G1-S phase transition, resulting in G0-G1 arrest.
Journal ArticleDOI
Cobalt carbonyl-mediated carbocyclizations of enynes: generation of bicyclooctanones or monocyclic alkenes.
TL;DR: Depending on the thermolytic conditions, dicobalthexacarbonyl-complexed enynes underwent cyclizations to provide different carbocyclic frameworks, which depicts another example of an interruption of the normal route in the Pauson-Khand reaction pathway.
Journal ArticleDOI
New directions for the Morita-Baylis-Hillman reaction; homologous aldol adducts via epoxide opening.
Marie E. Krafft,James A. Wright +1 more
TL;DR: Under trialkylphosphine catalyzed Morita-Baylis-Hillman reaction conditions, epoxides react with enones to give rise to homologous aldol adducts.
Journal ArticleDOI
11-Phenyl-[b,e]-dibenzazepine compounds: novel antitumor agents.
Raed A. Al-Qawasmeh,Yoon Sik Lee,Ming-Yu Cao,Xiaoping Gu,Stéphane Viau,Jeff Lightfoot,James A. Wright,Aiping H. Young +7 more
TL;DR: A series of 11-phenyl-[b,e]-dibenzazepine compounds were synthesized and shown to be inhibitors of tumor cell proliferation with IC(50) values ranging from submicromolar to micromolar concentrations.
Patent
Process for the manufacture of pharmaceutically active compounds
TL;DR: In this paper, the authors provided novel processes for the manufacture of the compound of formula (1) as well as novel synthesis routes for key intermediates used in those processes, and provided a novel synthesis route for key intermediate products.