James C. Vickers

TL;DR: Therapeutically, inhibition of the neuronal reaction to physical trauma may be a useful neuroprotective strategy in the earliest stages of Alzheimer's disease.

TL;DR: All morphologically defined beta-amyloid plaque variants were present in both early and late stages of Alzheimer's disease, and progression to clinical dementia was associated with both a shift to a higher proportion of fibrillar plaques that induced local neuritic alterations and a transformation of cytoskeletal proteins within associated abnormal neuronal processes.

TL;DR: Data indicate that NMDAR1-immunoreactive cells in neocortex represent a morphologically, functionally, and neurochemically heterogeneous population.

TL;DR: It is suggested that plaque-associated focal demyelination of the cortical grey matter might impair cortical processing, and may also be associated with aberrant axonal sprouting that underlies dystrophic neurite formation.

TL;DR: The literature reveals little consistent evidence that normal age‐related cognitive decline is moderated by education attainment, which supports a passive theory of cognitive reserve: people with a higher level of education will continue to perform at a higherlevel of cognitive functioning than their lower educated peers, which may delay the onset of impairment in the future.